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TranscriptomicsRNA-seq of human primary hepatocytes treated with FGF19 and CDCA
Primary human hepatocytes were treated with recombinant FGF19 (n=3), CDCA (n=3), endogenously produced FGF19 (n=3), or vehicle controls (n=3+3). Total RNA was harvested and sequenced with a strand-specific paired end RNA-seq protocol.
ORGANISM(S): Homo sapiens 
2021-02-13 | E-MTAB-8627 | biostudies-arrayexpress
TranscriptomicsEffect of FGF15 or FGF19 on mouse liver
Mouse FGF15 and human FGF19 are orthologous proteins that regulate bile acid metabolism. However, other hepatic functions of FGF15/19 are not well characterized. We used microarrays to analyze global hepatic gene expression in mice administered FGF15 or FGF19. Total liver RNA was isolated from wild...
ORGANISM(S): Mus musculus 
2011-06-07 | E-GEOD-29426 | biostudies-arrayexpress
ProteomicsQuantitative liver proteomics identifies FGF19 targets that couple metabolism and proliferation
Fibroblast growth factor 19 (FGF19) is a gut-derived peptide hormone that is produced following activation of Farnesoid X Receptor (FXR). FGF19 is secreted and signals to the liver, where it contributes to the homeostasis of bile acid (BA), lipid and carbohydrate metabolism. FGF19 is a promising the...
ORGANISM(S): Mus musculus (Mouse) 
2017-02-15 | PXD005659 | Pride
Fgf19  growth factor  fxr  liver  proteomics  metabolism  proliferation  tgf 
TranscriptomicsMicroRNA profiling of human primary hepatocytes treated with CDCA, GW4064 or FGF19
We studied the effect of bile acid CDCA, FXR agonsit GW4064 and FGF19 on the expression levels of microRNA in cultured human primary hepatocytes
ORGANISM(S): Homo sapiens 
2010-04-20 | E-TABM-691 | biostudies-arrayexpress
TranscriptomicsEffect of FGF19 and TNFalpha on human DU145 prostate cancer cells
DU145 prostate cancer cells were treated with 50 ng/ml FGF19 and 50 ug/ml heparin, or 10 ng/ml TNFalpha, or both drug treatment groups
ORGANISM(S): Homo sapiens 
2010-07-09 | E-GEOD-22807 | biostudies-arrayexpress
GenomicsLiver ChIP-seq analysis in FGF19-treated mice reveals SHP as a global transcriptional partner of SREBP-2
Background: Fibroblast growth factor-19 (FGF19) is an intestinal hormone that mediates postprandial metabolic responses in the liver. The unusual orphan nuclear receptor, Small Heterodimer Partner (SHP), acts as a co-repressor for many transcriptional factors and has been implicated in diverse biolo...
ORGANISM(S): Mus musculus 
2015-11-12 | E-GEOD-74913 | biostudies-arrayexpress
GenomicsRNA-seq of human primary hepatocytes treated with FGF19 and CDCA
RNA-seq of human primary hepatocytes treated with FGF19 and CDCA
PRJEB35934 | ENA
GenomicsEngineered FGF19 promotes HDL biogenesis and transhepatic cholesterol efflux to prevent atherosclerosis
Engineered FGF19 promotes HDL biogenesis and transhepatic cholesterol efflux to prevent atherosclerosis
PRJNA483446 | ENA
GenomicsFGF19 induces the inflammatory phenotype of LX-2 cells
FGF19 induces the inflammatory phenotype of LX-2 cells
PRJNA891228 | ENA
GenomicsAlleviating FGF19’s tumorigenic risk by suppressing its FGF Receptor dimerization ability
Alleviating FGF19’s tumorigenic risk by suppressing its FGF Receptor dimerization ability
PRJNA627107 | ENA
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