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TranscriptomicsFGFR3-shRNA induced transcriptional changes in RT112 bladder cancer cells
Aberrant activation of FGFR3 via overexpression or mutation is a frequent feature of bladder cancer; however, its molecular and cellular consequences and functional relevance to carcinogenesis are not well understood. In this study with a bladder carcinoma cell line expressing inducible FGFR3 shRNA...
ORGANISM(S): Homo sapiens 
2012-11-07 | E-GEOD-41035 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of glioblastoma cell lines transfected with FGFR3-TACC3
Gene expression profiling of SNB19 and U251 glioblastoma cell lines transfected with the FGFR3-TACC3 fusion, FGFR3 wildtype and TACC3 wildtype constructs. SNB19 and U251 cells were transfected with different clones of the FGFR3-TACC3 fusion and with wildtype FGFR3 and TACC3 constructs. Total RNA was...
ORGANISM(S): Homo sapiens 
2012-12-01 | E-GEOD-42401 | biostudies-arrayexpress
GenomicsGene expression data from UMUC-14 following FGFR3 knock-down using FGFR3 siRNAs
Gene expression data from UMUC-14 following FGFR3 knock-down using FGFR3 siRNAs
PRJNA516796 | ENA
GenomicsProfibrotic regulation of FGFR3 signaling in fibroblasts
Profibrotic regulation of FGFR3 signaling in fibroblasts
PRJNA625273 | ENA
TranscriptomicsMicroarray of Human astrocytes transduced with lentivirus expressing FGFR3-TACC3 treated with vehicle, FGFR3-TACC3 treated with the FGFR inhibitor PD173074 for 12h, FGFR3-TACC3-K508M treated with vehicle or empty vector treated with vehicle
In order to interrogate the transcriptional changes elicited by FGFR3-TACC3, we expressed the FGFR3-TACC3 fusion protein in human astrocytes and compared the global gene expression profiles of cells treated with a specific inhibitor of FGFR3-TK (PD173074) or vehicle. FGFR3-TACC3 expressing HA were a...
ORGANISM(S): Homo sapiens 
2017-10-17 | E-MTAB-6037 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human chondrocytes isolated from normal cartilage or thanatophoric dysplasia affected cartilage
Endochondral ossification is the process by which the appendicular skeleton, facial bones, vertebrae and medial clavicles are formed and relies on the tight control of chondrocyte maturation. Fibroblast growth factor receptor (FGFR)3 plays a role in bone development and maintenance and belongs to a ...
ORGANISM(S): Homo sapiens 
2009-12-27 | E-MEXP-2276 | biostudies-arrayexpress
GenomicsGene expression data from FGFR3 induced mouse bladder tumors
Gene expression data from FGFR3 induced mouse bladder tumors
PRJNA637591 | ENA
TranscriptomicsExpression data from lung of mice bearing mutations of FGFR3 and FGFR4
Gene expression profiling of newborn lung tissue revealed few changes in compound FGFR3/FGFR4 deficient mice, consistent with their normal lung morphology at birth, suggesting the sequence of events leading to the phenotype initiates after birth in this model. Profiling of 4 week-old lung tissues re...
ORGANISM(S): Mus musculus 
2010-04-12 | E-GEOD-15452 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat FGFR3-K650E mutant and wild type PC12 cells
To investigate signaling pathways activated by FGFR3 mutations through an analysis of altered expression of downstream transcriptional targets, we performed gene expression profiling of stably transfected inducible PC12 cells expressing a chimeric receptor (PFR3) consisting of the extracellular doma...
ORGANISM(S): Rattus norvegicus 
2007-10-08 | E-GEOD-2606 | biostudies-arrayexpress
TranscriptomicsGene expression data from UMUC-14 following FGFR3 knock-down using FGFR3 siRNAs
To better understand the molecular mechanisms underlying altered-FGFR3 oncogenic activity in bladder carcinomas, we made use of UMUC-14 cell lines, which endogenously expressed a mutated activated form of FGFR3 (FGFR3-S249C), the growth and transformation of these cell lines being dependent on activ...
ORGANISM(S): Homo sapiens 
2020-12-31 | GSE125547 | GEO
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