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ProteomicsIdentification of novel blood-borne soluble binding partners of factor H-related proteins
The deposition of circulating complement factor H-related (FHR) proteins in tissues around the body has been implicated in a series of complement-mediated diseases. However, the array of blood-borne binding partners with which they interact remains unclear. Here, we identify novel blood-borne bindin...
ORGANISM(S): Homo sapiens (Human) 
2026-03-30 | PXD072296 | Pride
Fhr Affinity proteomics Blood 
UnknownFactor H-Related (FHR)-1 and FHR-2 Form Homo- and Heterodimers, while FHR-5 Circulates Only As Homodimer in Human Plasma.
Not available
S-EPMC5651247 | biostudies-literature
UnknownFactor H-related 2 levels dictate FHR dimer composition.
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S-EPMC11950314 | biostudies-literature
UnknownDeficiency of Mouse FHR-1 Homolog, FHR-E, Accelerates Sepsis, and Acute Kidney Injury Through Enhancing the LPS-Induced Alternative Complement Pathway.
Not available
S-EPMC7316958 | biostudies-literature
UnknownHybrid-FHR: a multi-modal AI approach for automated fetal acidosis diagnosis.
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S-EPMC10801938 | biostudies-literature
UnknownFactor H-related protein 1 (FHR-1) is associated with atherosclerotic cardiovascular disease.
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S-EPMC8602345 | biostudies-literature
UnknownMolecular bases for the association of FHR-1 with atypical hemolytic uremic syndrome and other diseases.
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S-EPMC8288665 | biostudies-literature
UnknownComplement Regulator FHR-3 Is Elevated either Locally or Systemically in a Selection of Autoimmune Diseases.
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S-EPMC5124756 | biostudies-literature
UnknownFunctional and structural characterization of mouse Factor H-related B protein unveils a novel dimerization domain shared by FHR-B and FH.
Not available
S-EPMC11813886 | biostudies-literature
UnknownC3 glomerulopathy-associated CFHR1 mutation alters FHR oligomerization and complement regulation.
Not available
S-EPMC3668852 | biostudies-literature
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