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ProteomicsFibroblast-tracks are topographical cues that direct cancer cell migration
Fibroblasts rely on adhesive structures to migrate. It is generally thought that adhesive structures disassemble once at the rear of the cell to release the cell and allow further movement. However, a significant portion of adhesions is not disassembled and is instead left on the substrate. We obser...
ORGANISM(S): Homo sapiens (Human) 
2023-09-22 | PXD034091 | Pride
Cancer Cafs Extracellular matrix 
TranscriptomicsClaudin 1 mediates TNF alpha-induced gene expression and cell migration in human lung carcinoma cells
Epithelial-mesenchymal transition (EMT) is an important mechanism in carcinogenesis. To determine the mechanisms that are involved in the regulation of EMT is crucial to develop new biomarkers and therapeutic targets towards cancers. In this study, when TGFß1 and TNFa were used to induce EMT in hum...
ORGANISM(S): Homo sapiens 
2012-06-12 | E-GEOD-32254 | biostudies-arrayexpress
TranscriptomicsTranscriptional networks identify synaptotagmin-like 3 as a regulator of cortical neuronal migration during early neurodevelopment
Human brain development is a complex process involving neural proliferation, differentiation, and migration which are directed by many essential cellular factors and drivers. Here, using the NetBID2 algorithm and developing human brain RNA sequencing(RNA-Seq) dataset, we identified synaptotagmin-lik...
ORGANISM(S): Homo sapiens 
2021-02-07 | E-MTAB-10058 | biostudies-arrayexpress
GenomicsTargeting the Epigenome Reduces Keloid Fibroblast Cell Proliferation, Migration and Invasion
Targeting the Epigenome Reduces Keloid Fibroblast Cell Proliferation, Migration and Invasion
PRJNA970758 | ENA
GenomicsFunctional CRISPR-Cas9 knockout screening of the genetic determinants of human fibroblast migration propensity
Functional CRISPR-Cas9 knockout screening of the genetic determinants of human fibroblast migration propensity
PRJNA1106404 | ENA
TranscriptomicsTranscription profiling of mouse fibroblasts expressing different Fibroblast Growth Factor-2 forms
Fibroblast Growth Factor-2 (FGF-2) induces cell proliferation, cell migration, embryonic development, cell differentiation, angiogenesis and malignant transformation. The four forms of FGF-2 (Low Molecular Weight) and (High Molecular Weights) are alternative translation products, and have a differen...
ORGANISM(S): Mus musculus 
2006-11-11 | E-SMDB-3872 | biostudies-arrayexpress
Proteomics3D Mechanical Stimulation Modulates Endothelial Exosomes to Promote Fibroblast Activation
Background: Mechanical forces play a crucial role in regulating cellular communication during tissue repair, yet how mechanical stimulation modulates endothelial exosome secretion and their effects on fibroblast activation remains unclear. Methods: In this study, endothelial cells were incorporated ...
ORGANISM(S): Homo Sapiens 
2025-12-25 | PXD072415 |
TranscriptomicsDNA methylome signature in rheumatoid arthritis
Objectives: Epigenetics can influence disease susceptibility and severity. While DNA methylation of individual genes has been explored in autoimmunity, no unbiased systematic analyses have been reported. Therefore, a genome-wide evaluation of DNA methylation loci in fibroblast-like synoviocytes (FLS...
ORGANISM(S): Homo sapiens 
2013-04-25 | E-GEOD-46364 | biostudies-arrayexpress
GenomicsLysyl hydroxylase 2 deficiency promotes filopodia formation and fibroblast migration
Lysyl hydroxylase 2 deficiency promotes filopodia formation and fibroblast migration
PRJNA772615 | ENA
Proteomicsintercardiac Phosphoproteome/proteome regulation of cardiomyocyte-fibroblast signaling
Secretome-mediated signaling from human iPSC-derived cardiomyocytes (TGF-beta induced dysfunction) to primary human cardiac fibroblasts was investigated to identify downstream regulators of fibrosis. Quantitative proteomic profiling revealed a dynamic reprogramming of fibroblast global proteome, wit...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-06-27 | MSV000092293 | MassIVE
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