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TranscriptomicsMiRNA expression analysis of cancer-associated fibroblasts (CAFs) and normal fibroblasts (NFs) in breast cancer
To identify miRNA differentially expressed in CAFs vs matched NFs and analyze the heterogeneity of miRNA expression profiles in the two kinds of cells, we established primary cultures of CAFs and paired NFs from six resected breast tumor tissue without any radiotherapy and chemotherapy treatment. Pa...
ORGANISM(S): Homo sapiens 
2012-09-28 | E-GEOD-37527 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression profiling of CAFs before and after chemotherapy in human breast cancer microenvironment
We investigated the chemotherapy-induced response of primary-cultured CAFs and compared its gene expression profiling before and after chemotherapy treatment.
ORGANISM(S): Homo sapiens 
2014-06-27 | E-MTAB-1614 | biostudies-arrayexpress
TranscriptomicsA cancer associated fibroblasts (CAFs) specific gene signature in high grade serous ovarian cancer
Ovarian cancer is the most lethal malignancy in the United States. In the year 2012, there will be an estimated 22,280 new cases and 15,500 deaths from ovarian cancer in the country (Siegel et al., 2012). While studies on ovarian cancer pathogenesis were mainly focused on the epithelial component of...
ORGANISM(S): Homo sapiens 
2014-09-11 | E-GEOD-40595 | biostudies-arrayexpress
TranscriptomicsExpression data from gemcitabine treated pancreatic CAFs
Pancreatic ductal adenocarcinoma (PDAC) has a characteristically dense stroma comprised predominantly of cancer associated fibroblasts (CAFs). CAFs promote tumor growth, metastasis and treatment resistance. We aimed to investigate the molecular changes and functional consequences associated with che...
ORGANISM(S): Homo sapiens 
2016-03-09 | E-GEOD-78982 | biostudies-arrayexpress
TranscriptomicsGenes activated by 5-aza-dC (DAC) in pancreatic (KPC-Brca1) cancer-associated fibroblasts (CAFs)
Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy that resists current treatments. To test epigenetic therapy against this cancer we used the DNA demethylating drug 5-aza-2’-deoxycytidine (DAC) in a KrasLSL-G12D; p53LSL-R270H/+; Pdx1-cre; Brca1flex2/flex2 (KPC-Brca1) mouse model of agg...
ORGANISM(S): Mus musculus 
2013-01-01 | E-GEOD-42364 | biostudies-arrayexpress
TranscriptomicsExpression data from (mouse) normal lung fibroblasts and carcinoma-associated fibroblasts
Cancer-associated fibroblasts (CAFs) have been reported to support tumor progression by a variety of mechanisms. However, their role in the progression of non-small cell lung cancer (NSCLC) remains poorly defined. In addition, the extent to which specific proteins secreted by CAFs contribute directl...
ORGANISM(S): Mus musculus 
2013-07-10 | E-GEOD-48397 | biostudies-arrayexpress
ProteomicsLncRNA NEAT1 promotes immunosuppression in gastric cancer by maintaining the m6A methylation of SEMA3A in CAFs via exosomes under endoplasmic reticulum stress
Endoplasmic reticulum stress (ERS) regulates the function of immune cells in the tumor microenvironment and suppresses the antitumor immune response. In order to formulate the TME of ERS-GC, we cocultured the human CAFs with the supernatant of human gastric cancer cells stimulated by TM. Mass spectr...
ORGANISM(S): Homo sapiens (Human) 
2026-04-13 | PXD061686 | Pride
Humon sgc7901 endoplasmic reticulum stress (ers) 
ProteomicsTo investigate how Trametinib affects colorectal CAFs in ECM production and remodeling
Data independent acquisition (DIA) mass spectrometry was used to study the role of the MEK1/2 inhibitor Trametinib on the ability of colorectal CAFs to produce and modify the extracellular matrix
ORGANISM(S): Homo sapiens (Human) 
2026-02-12 | PXD058691 | Pride
Cafs Trametinib Dia mass spectrometry Faims-orbitrap lumos 
ProteomicsCD9, a key mediator of pancreatic cancer cell aggressiveness driven by CAFs-derived extracellular vesicles
While of growing interest in pancreatic cancer (PC) field, the stromal-tumor cells crosstalk lags behind in terms of biomarkers and therapeutic options improving the clinical armamentarium. Knowledge on cellular communications was drastically enhanced following the discovery of extracellular vesicle...
ORGANISM(S): Homo sapiens (Human) 
2022-08-21 | PXD023165 | Pride
Lc-msms Cd9 Migration Cancer-associated fibroblasts (cafs) Extra-cellular vesicles (evs) P38/mapk pathway Stromal compartment Pancreatic cancer (pc) 
GenomicsConophylline effect on CAFs in HCC
Conophylline effect on CAFs in HCC
PRJNA590141 | ENA
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