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MetabolomicsLipidomic analysis of Drosophila on different sugar feeding regimes +/- trametinib

Consumption of sugar-rich diets adversely affects health and reduces life expectancy through the excessive production and storage of triacylglycerides (TAGs) leading to metabolic dysfunction. Here, using Drosophila melanogaster, we identify the conserved Ras/MAPK signalling pathway as a key media...

2026-09-02 | MTBLS14468 | MetaboLights
ProteomicsTo investigate how Trametinib affects colorectal CAFs in ECM production and remodeling
Data independent acquisition (DIA) mass spectrometry was used to study the role of the MEK1/2 inhibitor Trametinib on the ability of colorectal CAFs to produce and modify the extracellular matrix
ORGANISM(S): Homo sapiens (Human) 
2026-02-12 | PXD058691 | Pride
Cafs Trametinib Dia mass spectrometry Faims-orbitrap lumos 
TranscriptomicsPredominance of MAPK reactivation in early resistance to debrafenib/trametinib combination therapy of BRAF mutant metastatic melanoma.
One third of BRAF-mutant metastatic melanoma patients treated with combined BRAF and MEK inhibition progress within six months. Treatment options for these patients remain limited. Here we analyse twenty BRAFV600 mutant melanoma metastases derived from 10 patients treated with the combination of deb...
ORGANISM(S): Homo sapiens 
2014-12-03 | E-GEOD-61992 | biostudies-arrayexpress
TranscriptomicsRNA-seq of Drosophila exposed to trametinib under normal and high sugar dietary conditions
The transcriptional response to the small molecule MEK inhbitor, trametinib, was analysed from RNA extracts prepared from 10-day old adult female Drosophila that had been maintained under normal and high sugar dietary conditions post-eclosion.
ORGANISM(S): Drosophila melanogaster 
2026-09-03 | E-MTAB-17017 | biostudies-arrayexpress
TranscriptomicsHuman BRAF-V600E melanoma cell lines drug sensitive vs drug resistant
aCGH of human melanoma cell lines comparing parental (drug sensitve) vs isogenic drug resistant-derived subline Two condition experiment: two BRAF-V600E mutant cell lines (drug sensitive - parental baseline) vs two derived sublines after chronic exposure to the MEK inhibitor trametinib (drug resista...
ORGANISM(S): Homo sapiens 
2014-04-21 | E-GEOD-49430 | biostudies-arrayexpress
TranscriptomicsRNAseq of A375 melanoma cells and A375 with ARID1A KO in control conditions and treatment with trametinib, vemurafenib or combination
The experiment aimed to study mechanisms of melanoma drug resistance. ARID1A confers resistance to trametinib and therefore RNAseq was collected alongside other omics data for parental A375 likes, and A375 lines with ARID1A KO, in the presence of no drug, trametinib, vemurafenib or their combination
ORGANISM(S): Homo sapiens 
2025-02-18 | E-MTAB-14759 | biostudies-arrayexpress
GenomicsModulation of medaka transcriptome by trametinib and cisplatin
Modulation of medaka transcriptome by trametinib and cisplatin
PRJNA470026 | ENA
GenomicsResponse and resistance of low grade ovarian cancer cells to trametinib
Response and resistance of low grade ovarian cancer cells to trametinib
PRJNA625278 | ENA
GenomicsWhole-exome sequencing of genomic DNA from patient-derived melanoma cell lines resistant to either vemurafenib (PLX) or trametinib (TRA).
Whole-exome sequencing was performed on DNA samples extracted from seven melanoma cell lines resistant to either vemurafenib (BRAF V600E inhibitor) or trametinib (MEK1/2 inhibitor). The aim of the experiment was to search for genetic alterations responsible for phenotypic diversity of melanoma cell ...
ORGANISM(S): Homo sapiens 
2019-06-15 | E-MTAB-7991 | biostudies-arrayexpress
GenomicsWhole-exome sequencing of genomic DNA extracted from patient-derived melanoma cell lines resistant to vemurafenib (PLX) or trametinib (TRA)
Whole-exome sequencing was performed on DNA samples extracted from seven melanoma cell lines resistant to either vemurafenib (BRAF V600E inhibitor) or trametinib (MEK1/2 inhibitor). The aim of the experiment was to search for genetic alterations responsible for phenotypic diversity of melanoma cell ...
ORGANISM(S): Homo sapiens 
2018-10-20 | E-MTAB-7248 | biostudies-arrayexpress
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