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MetabolomicsDNA nanomachines reveal an adaptive energy mode in confinement-induced amoeboid migration powered by polarized mitochondrial distribution

Energy metabolism is highly interdependent with adaptive cell migration in vivo. Mechanical confinement is a critical physical cue that induces switchable migration modes of the mesenchymal-to-amoeboid transition (MAT). However, the energy states in distinct migration modes, especially a...

2024-03-25 | MTBLS9657 | MetaboLights
MetabolomicsCHML regulates migration and invasion in hepatocellular carcinoma via transcriptional and metabolic reprogramming

Hepatocellular carcinoma (HCC), a prevalent malignant neoplasm, presents significant therapeutic challenges. However, the key factors and mechanisms driving HCC metastasis remain incompletely understood. This study aimed to elucidate the mechanism through which CHML regulates the migration and in...

2025-07-28 | MTBLS12789 | MetaboLights
MetabolomicsSphingomyelin depletion inhibits CXCR4 dynamics and CXCL12-mediated directed cell migration in human T cells
Not available
ORGANISM(S): Homo sapiens 
ST002150 | MetabolomicsWorkbench
ProteomicsLocal RNA translation controls cell migration and Rab GTPase function
Numerous RNAs exhibit specific distribution patterns in mammalian cells. However, the functional and mechanistic consequences are relatively unknown. We investigate here the functional role of RNA localization at cellular protrusions of mesenchymal migrating cells, using as a model the RAB13 RNA, wh...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-08-01 | MSV000085883 | MassIVE
TranscriptomicsTranscriptional networks identify synaptotagmin-like 3 as a regulator of cortical neuronal migration during early neurodevelopment
Human brain development is a complex process involving neural proliferation, differentiation, and migration which are directed by many essential cellular factors and drivers. Here, using the NetBID2 algorithm and developing human brain RNA sequencing(RNA-Seq) dataset, we identified synaptotagmin-lik...
ORGANISM(S): Homo sapiens 
2021-02-07 | E-MTAB-10058 | biostudies-arrayexpress
ProteomicsRNF185 control of COL3A1 expression limits prostate cancer migration and metastatic potential.
RNF185 is a RING finger domain-containing ubiquitin ligase implicated in ER-associated degradation. Prostate tumor patient data analysis revealed a negative correlation between RNF185 expression and prostate cancer progression and metastasis. Likewise, several prostate cancer cell lines exhibited gr...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-09 | PXD045473 | Pride
Ubiquitin ligase  rnf185  prostate adenocarcinoma  metastasis  epithelial-mesenchymal transition (emt)  collagen 
UnknownBibliometric analysis of global migration health research in peer-reviewed literature (2000-2016).
Not available
S-EPMC6011263 | biostudies-literature
TranscriptomicsPARVB overexpression increases migration capability and defines high risks for endophytic growth and metastasis in tongue squamous cell carcinoma.
Tongue squamous cell carcinoma (TSCC) varies in characteristics even in early stages and is mainly classified into three subtypes, which are superficial, exophytic and endophytic types, based on a macroscopic appearance of tumor growth.Of these subtypes, endophytic tumor has a poorer prognosis becau...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-52915 | biostudies-arrayexpress
ProteomicsProteome of neutrophils upon migration towards inflamed synovial fluid
Analysis of neutrophil proteomic alterations induced by migration towards inflamed joints in juvenile idiopathic arthritis (JIA). In this experiment neutrophil proteomes were investigated after migration towards JIA synovial fluid in an in vitro model of a synovial membrane, compared to neutrophils ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD029129 | Pride
Juvenile idiopathic arthritis Migration Synovial fluid Neutrophil 
GenomicsMigration-related phenotypic divergence is associated with epigenetic variation in rainbow trout
Migration is essential for the reproduction and survival of many animals, yet little is understood about its underlying molecular mechanisms. We used the salmonid Oncorhynchus mykiss to gain mechanistic insight into smoltification, which is a morphological, physiological, and behavioral transition u...
ORGANISM(S): Oncorhynchus mykiss 
2015-06-18 | E-GEOD-62195 | biostudies-arrayexpress
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