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TranscriptomicsProfiling uterine fibroid specimens with an in-house array representing all 90 human tyrosine kinases and their ligands
The aim of this study is to compare the expression patterns of tyrosine kinases and their ligand activators between matched myometrium and leiomyoma tissues. For this, total RNA samples extracted from 42 pairs of matched fibroid and adjacent myometrial tissues were hybridized to a set of 840 customi...
ORGANISM(S): Homo sapiens 
2009-11-20 | E-GEOD-19127 | biostudies-arrayexpress
TranscriptomicsMyomgraft_Model_TASIP_2010_09
Human uterine fibroids are benign tumors derived from the smooth muscle layers of the uterus. Fibroid disease impacts up to 50% of premenopausal women in their daily life, and accounts for up to 50% of hysterectomies in the United States. Despite the health burden they impose, the development of the...
ORGANISM(S): Homo sapiens 
2014-05-01 | E-MTAB-1882 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human mayometrium and uterine fibroids with normal and non-normal karyotypes
Normal myometrium and uterine fibroids (partially paired from the same donor) were profiled. FISH analysis was used to analyze the karyotype of the uterine fibroid samples. This study provides further insights in the development of uterine fibroids. Additional uterine fibroid samples from the same s...
ORGANISM(S): Homo sapiens 
2023-07-01 | E-MTAB-12550 | biostudies-arrayexpress
TranscriptomicsGenome-Wide Progesterone Receptor Binding: Cell Type-Specific and Shared Mechanisms in Uterine Fibroids and Breast Cancer (Expression BeadChip)
Analysis of genes regulated by RU486 (an progesterone antagonist) in human breast cancer T47D cells and human uterine leiomyoma smooth muscle cells. The hypothesis is that RU486 inhibits tumor growth by inactivating the transcription of multiple genes which trigger critical signaling pathways to ind...
ORGANISM(S): Homo sapiens 
2012-09-11 | E-GEOD-40725 | biostudies-arrayexpress
GenomicsGenome-Wide Progesterone Receptor Binding: Cell Type-Specific and Shared Mechanisms in Uterine Fibroids and Breast Cancer (ChIP-Seq)
Analysis of genes regulated by RU486 (an progesterone antagonist) in human breast cancer T47D cells and human uterine leiomyoma smooth muscle cells. The hypothesis is that RU486 inhibits tumor growth by inactivating the transcription of multiple genes which trigger critical signaling pathways to ind...
ORGANISM(S): Homo sapiens 
2012-09-11 | E-GEOD-40724 | biostudies-arrayexpress
GenomicsTranscriptomic and Functional Analysis of Fibroid Extracellular Vesicles
Transcriptomic and Functional Analysis of Fibroid Extracellular Vesicles
PRJNA1446846 | ENA
TranscriptomicsTranscription profiling of human uterine fibroid (leiomyoma) and normal myometrial tissue to identify differentially expressed genes
Our study seeks to identify genes differentially expressed between uterine leiomyomas and normal myometrial tissue. This series consists of samples derived from normal myometrium and uterine leiomyomas obtained from fibroid afflicted patients.Total RNA was extracted from samples, converted to biotin...
ORGANISM(S): Homo sapiens 
2007-09-28 | E-GEOD-593 | biostudies-arrayexpress
TranscriptomicsAnalysis of the purified RNA samples to confirm that Notch pathway activation inhibits apoptosis in uterine leiomyomas leading to fibroid growth
Uterine leiomyomas are the most common benign tumor in humans causing significant morbidity with vaginal bleeding, pelvic pressure and pain. Histologically, leiomyomas show a large degree of extracellular matrix disorganization. I am working with a colleague who recently found Notch pathway gene ...
ORGANISM(S): Homo sapiens 
2011-04-29 | E-GEOD-28945 | biostudies-arrayexpress
GenomicsTranscriptome Analyses of Myometrium from Fibroid Patients Reveals Phenotypic Differences Compared to Non-diseased Myometrium
Transcriptome Analyses of Myometrium from Fibroid Patients Reveals Phenotypic Differences Compared to Non-diseased Myometrium
PRJNA715909 | ENA
GenomicsNext-Generation Sequencing Facilitates Quantitative Analysis of Control and BRD9 Inhibitors-treated Uterine Fibroid Cell Transcriptome
Next-Generation Sequencing Facilitates Quantitative Analysis of Control and BRD9 Inhibitors-treated Uterine Fibroid Cell Transcriptome
PRJNA802199 | ENA
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