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MetabolomicsA single gene mutation underpins metabolic adaptation and acquisition of filamentous competence in the emerging fungal pathogen Candida auris

Filamentous cell growth is a vital property of fungal pathogens. The mechanisms of filamentation in the emerging multidrug-resistant fungal pathogen Candida auris are poorly understood. Here, we show that exposure of C. auris to glycerol triggers a rod-like filamentation-competent (RL-FC) phenoty...

2024-07-04 | MTBLS9053 | MetaboLights
MetabolomicsEndophytic mycobiont provides growth benefits via a Phenylpropanoid-Auxin axis in host plants

Beneficial association with symbiotic fungi helps improve the growth and fitness in most land plants, and shows great potential as biofertilizers in precision agriculture. Here, we demonstrated that a root fungal endophyte, Tinctoporellus species isolate AR8, enabled yield improvement in...

2025-04-11 | MTBLS12374 | MetaboLights
MetabolomicsThe synergistic growth promoting mechanism of ""internal and external"" microbiota for maize growth mediated by dark septate endophytes

BACKGROUND: The coevolution and interaction between plants and microorganisms have long been a subject of significant research interest. Dark septate endophytes (DSE) have garnered great attention in contemporary research due to their functional diversity, in vitro cultivation ab...

2023-12-15 | MTBLS8903 | MetaboLights
MetabolomicsSynthetic Microbial Communities Improve Wheat Stem Base Rot and Promote Wheat Growth by Regulating Rhizosphere Microbial Communities

Background

Wheat crown rot (WCR) caused by Fusarium spp. lacks durable, sustainable control. Engineering the rhizosphere with defined synthetic microbial communities (SynComs) offers a route to combined disease suppression and growth promotion. We aimed to build a cross-kingdom SynCom and e...

2025-09-06 | MTBLS12945 | MetaboLights
MetabolomicsTime-resolved decoding of metabolic signatures of in vitro growth of the hemibiotrophic pathogen Colletotrichum sublineolum
Metabolomics has emerged as a powerful approach to comprehensively interrogate cellular biochemistry. As such, we applied an untargeted liquid chromatography-mass spectrometry metabolomic strategy to elucidate metabolome changes in the anthracnose-causing hemibiotrophic sorghum pathogen, Colletotric...
2022-05-30 | MTBLS735 | MetaboLights
TranscriptomicsTranscriptomic response to substrate and temperature in two thermophilic fungi, Myceliophthora thermophila and Thielavia terrestris, and a related mesophile, Chaetomium globosum
The thermophilic filamentous fungi Myceliophthora thermophila (Sporotrichum thermophile) and Thielavia terrestris are proficient decomposers of cellulose, suggesting that they will be a rich source of thermostable industrial enzymes for lignocellulose degradation. To identify the genes and proteins...
ORGANISM(S): Myceliophthora thermophila 
2011-08-08 | E-GEOD-27323 | biostudies-arrayexpress
MetabolomicsRhizophagus intraradices improves soybean microbiome niche under saline-alkaline stress across critical growth stages

Background

Soil salinization and alkalization severely threaten soybean growth and yield. Arbuscular mycorrhizal fungi (AMF), specifically Rhizophagus intraradices (Ri), enhance stress tolerance and soil quality, yet their mechanisms in regulating microbial-metabolite interactions during cr...

2026-01-12 | MTBLS13661 | MetaboLights
MetabolomicsSynergistic regulation of Codonopsis pilosula growth and metabolism by Trichoderma, salicylic acid and methyl jasmonate
Endophytic fungi can mediate salicylic acid (SA)- and methyl jasmonate (MeJA)-related signaling in medicinal plants, thereby influencing metabolite synthesis, stress resistance, and growth development. Experimental groups comprised control, Trichoderma longibrachiatum inoculation (FG), FG+SA (FS), F...
2026-04-22 | MTBLS14304 | MetaboLights
MetabolomicsSynergistic regulation of Codonopsis pilosula growth and metabolism by Trichoderma, salicylic acid and methyl jasmonate
Endophytic fungi can mediate salicylic acid (SA)- and methyl jasmonate (MeJA)-related signaling in medicinal plants, thereby influencing metabolite synthesis, stress resistance, and growth development. Experimental groups comprised control, Trichoderma longibrachiatum inoculation (FG), FG+SA (FS), F...
2026-04-16 | MTBLS14293 | MetaboLights
ProteomicsQuantitiative phosphoproteomic analysis of SKS1 signaling network involved in yeast filamentous growth by LC-MS in combination with SILAC
Yeast pseudohyphal growth(filamentous growth) is regulated by signaling pathways responsive to nitrogen stress and glucose deprivation, but the molecular link between pseudohyphal filamentation and glucose signaling is not fully understood. To identify the Sks1p signaling network involved in filamen...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2014-04-16 | PXD000414 | Pride
Phosphoproteome Lc-ms Filamentous growth Silac Saccharomyces cerevisiae Sks1 
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