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ProteomicsA mouse model of Fragile X Syndrome analyzed by quantitative proteomics: a comparison of methods
We have compared the performance of seven different strategies in the analysis of a mouse model of Fragile X Syndrome, involving the knockout of the fmr1 gene that is the leading cause of autism spectrum disorder. Focusing on the cerebellum, we show that Data-Independent Acquisition (DIA) and the TM...
ORGANISM(S): Mus musculus (Mouse) 
2023-08-21 | PXD039885 | Pride
Quantitative proteomics Boxcar Complementary ion quantification Dia Method comparison Label-free Tmt labeling Mouse brain proteomics Fragile x syndrome 
ProteomicsMicrobiome-derived hydroxyphenyl propanoate promotes antitumour immunity by enhancing Gasdermin D cleavage in tumour-associated myeloid cells
The microbiome has a significant impact on immune health and response to immune-stimulating treatments, including cancer immunotherapy. However, the molecular mechanisms by which commensal microbes influence cancer immunology remain poorly understood. Here, we report on the discovery of a class of m...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD045790 | Pride
Tmt Gasdermin d Hydroxuphenyl pyruvate Thermal profiling Thp1-dual cells 
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