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TranscriptomicsExpression profiling of murine E10.5 TLR2+ CD11b+ embryonic phagocytes by comparative microarray analyses
The detection of Toll-like receptor 2 (TLR2) expression on E10.5 early embryonic phagocytes prompted us to determine the list of markers co-expressed with TLR2 in a cell-type specific manner. Thus, a comparative expression profiling of cDNAs between murine E10.5 TLR2+ CD11b+ embryonic cells and TLR2...
ORGANISM(S): Mus musculus 
2014-12-01 | E-MTAB-1537 | biostudies-arrayexpress
TranscriptomicsRNA-seq of mouse ileum to investigate the role of IL-17 receptor signaling in Paneth cells in their biology and intestinal physiology
IL-17 receptor plays a major role in the antibacterial defense and regulation of host-microbiota interaction. However its impact on Paneth cells, cell-type specific for production of antibacterial peptides, is still not clear. Here, we used genetic depletion of IL-17 receptor specific for Paneth cel...
ORGANISM(S): Mus musculus 
2022-01-01 | E-MTAB-10038 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA sequencing of thymic dendritic cells reveals molecular determinants of antigen transfer in the thymus
The presentation of self-antigens in the thymus by medullary thymic epithelial cells (mTECs) and dendritic cells (DCs) is crucial for the establishment of central tolerance. While mTECs produce and present self-antigens in an autonomous manner, DCs acquire them from mTECs by Cooperative Antigen Tran...
ORGANISM(S): Mus musculus 
2024-07-31 | E-MTAB-14319 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by sequencing of murine MyD88 -/- and MyD88 +/+ mTECs stimulated with a TLR9 ligand
We compared in vitro mTECs-high stimulated with TLR9 ligand CpG ODN (1826) or non stimulated from MyD88 -/- and MyD88 +/+ mice: Thymi were enzymaticaly digested, cells were MACS enriched for CD45- fraction, and FACS sorted using BD Influx sorter. mTECs-high were gated as EpCAM+CD11c-Ly51-MHCII+CD80+...
ORGANISM(S): Mus musculus 
2020-03-20 | E-MTAB-8025 | biostudies-arrayexpress
TranscriptomicsRNA-sequencing of Aire-ILC3 cells from wild-type and Aire-deficient mice
Autoimmune regulator (Aire) plays an indispensable role in the induction of central immune tolerance. We identify a novel subset of Rorγt-dependent innate lymphoid cell-type in secondary lymphoid organs, which presents endogenously generated antigens and contributes to peripheral T cell tolerance. I...
ORGANISM(S): Mus musculus 
2019-03-14 | E-MTAB-7088 | biostudies-arrayexpress
TranscriptomicsTranscriptome profile of peripheral blood mononuclear cells in patients with type I diabetes and their first grade relatives
Type 1 Diabetes (T1D) is considered to be a Th1 autoimmune disease characterised by an absolute lack of insulin caused by an autoimmune destruction of the insulin producing pancreatic beta cells. Th1 lymphocytes are responsible for the infiltration of the islets of Langerhans and for the cytokine re...
ORGANISM(S): Homo sapiens 
2011-05-09 | E-GEOD-29142 | biostudies-arrayexpress
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