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ProteomicsTissue protease activity with MALDI MSI
Aberrant protease activity has been implicated in the etiology of various prevalent diseases including neurodegeneration and cancer, in particular metastasis. Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) has recently been established as a key technology for bio...
ORGANISM(S): Bos Taurus (ncbitaxon:9913) Mus Musculus (ncbitaxon:10090) 
MSV000086102 | MassIVE
ProteomicsHippocampal synaptoproteomic changes of susceptibility and resilience of rats to chronic social isolation
The susceptibility to chronic social isolation (CSIS) is associated with development of major depression (MD). Recent studies relate MD with altered expression of synaptic proteins in specific brain regions, whereby some individuals exposed to the stressors are resistant to the stress. To explore th...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-11-27 | PXD019790 | Pride
Synaptosomal fraction Rat Hippocampus Proteomics Lc-ms/ms 
ProteomicsSocial isolation stress-resilient rats reveal energy metabolic shift in hippocampal nonsynaptic mitochondria
We investigated the relative quantification of proteins in hippocampal cytosolic and nonsynaptic mitochondrial (NSM) fractions of rats exposed to chronic social isolation (CSIS), an animal model of depression, comparing CSIS-resilient with CSIS-sensitive or control rats, via a comparative subproteom...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-05-25 | PXD016966 | Pride
Resilience Hippocampus Rat Proteome Nonsynaptic mitochondria Lc-ms/ms 
ProteomicsFluoxetine triggers synaptic vesicle exo/endocytosis, mitochondrial energy metabolism and dynamics in hippocampus of socially isolated rats
We used comparative proteomic approach to identify proteome changes in purified synaptic terminals (synaptosomes) of rats exposed to chronic social isolation (CSIS) (6 weeks), animal model for depression, followed by chronic Fluoxetine treatment (last 3 weeks of CSIS) (therapeutic effect). Our aim w...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-03-11 | PXD028816 | Pride
Proteomics Rat Lc-ms Hippocampus 
ModelsSchliemann2011_TNF_ProAntiApoptosis
This model is from the article: Heterogeneity Reduces Sensitivity of Cell Death for TNF-Stimuli Schliemann M, Bullinger E, Borchers S, Allgower F, Findeisen R, Scheurich P. BMC Syst Biol. 2011 Dec 28;5(1):204. 22204418 , ...
2024-09-02 | BIOMD0000000407 | BioModels
ProteomicsProteomic analysis of hippocampal synaptosomes in chronically socially isolated rats: effect of antidepressant tianeptine
Dysregulation of brain synaptic proteins caused by chronic psychosocial stress has been linked with the development of major depression (MD). To gain insights into the pattern of synaptic proteome changes and different biological functions and pathways underlying MD and drug action, a comparative pr...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-02-16 | PXD021920 | Pride
Rat Hippocampus Proteomics Lc-ms/ms 
UnknownQuantitative imaging of electric surface potentials with single-atom sensitivity.
Not available
S-EPMC6656579 | biostudies-literature
UnknownElectrostatic potentials of atomic nanostructures at metal surfaces quantified by scanning quantum dot microscopy.
Not available
S-EPMC10937982 | biostudies-literature
UnknownGenetic risk variants for membranous nephropathy: extension of and association with other chronic kidney disease aetiologies.
Not available
S-EPMC5837679 | biostudies-literature
TranscriptomicsNeisseria meningitidis elicits a pro-inflammatory response involving IM-NM-:BM-NM-6 in a human blood-cerebrospinal fluid barrier model.
The human-specific, Gram-negative bacterium Neisseria meningitidis (Nm) is a leading cause of bacterial meningitis world-wide. It has been described that Nm can enter the central nervous system via the blood-cerebrospinal fluid barrier (BCSFB), which is constituted by the epithelial cells of the cho...
ORGANISM(S): Homo sapiens 
2014-09-16 | E-GEOD-42870 | biostudies-arrayexpress
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