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MetabolomicsMetabolic Dynamics of In Vitro CD8+ T Cell Activation

CD8+ T cells detect and kill virally infected or cancerous cells. When activated from their naïve state, T cells undergo a complex transition, including major metabolic reprogramming. Detailed resolution of metabolic dynamics of a wide range of metabolites is needed to advance the field of immuno...

2021-06-02 | MTBLS2145 | MetaboLights
TranscriptomicsTranscription profiling of human aortic biopsy samples having differing degrees of stiffness
BACKGROUND: Previous genomic studies with human tissues have compared differential gene expression between 2 conditions (ie, normal versus diseased) to identify altered gene expression in a binary manner; however, a potentially more informative approach is to correlate the levels of gene expression ...
ORGANISM(S): Homo sapiens 
2007-12-13 | E-GEOD-420 | biostudies-arrayexpress
TranscriptomicsThe small RNA diversity from Medicago truncatula roots under biotic interactions evidences the environmental plasticity of the miRNAome
Plants show a remarkable plasticity to adapt their root architecture to biotic and abiotic constraints of the soil environment. Although some of these modifications are fine-tuned by miRNAs, there are still shadow zones in these regulations. In the model legume Medicago truncatula, we analyzed the ...
ORGANISM(S): Medicago truncatula 
2014-08-15 | E-GEOD-49226 | biostudies-arrayexpress
TranscriptomicsGene analysis of intracellular and extracellular Streptococcus pyogenes in human macrophages
The objective of this study was to investigate which genes are important for Streptococcus pyogenes during intracellular survival in human macrophages. Streptococcus pyogenes is an important human pathogen, which has recently gained recognition as an intracellular microorganism during the course of ...
ORGANISM(S): Streptococcus pyogenes 
2011-09-14 | E-GEOD-32130 | biostudies-arrayexpress
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