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ProteomicsE3 ligase substrate adaptor SPOP fine tunes the UPR of pancreatic beta cells
The Cullin 3 E3 ligase adaptor protein, SPOP, targets proteins for ubiquitination and proteasomal degradation. We previously established the β cell transcription factor (TF) and human diabetes gene PDX1 as an SPOP substrate, suggesting a functional role for SPOP in the β cell. Here, we generated a β...
ORGANISM(S): Mus musculus (Mouse) 
2024-11-12 | PXD052527 | Pride
E3 ligase Pdx1 Spop Proteasomal degradation Diabetes 
TranscriptomicsAlterations in Gene Expression in Human Mesothelial Cells Correlate with Mineral Pathogenicity
Human mesothelial cells (LP9/TERT-1) were exposed to low and high (15 and 75 μm2/cm2 dish) equal surface area concentrations of crocidolite asbestos, nonfibrous talc, fine titanium dioxide (TiO2), or glass beads for 8 or 24 h. RNA was then isolated for Affymetrix microarrays, GeneSifter analysis and...
ORGANISM(S): Homo sapiens 
2011-09-18 | E-GEOD-14034 | biostudies-arrayexpress
Transcriptomics8-chip high-resolution aCGH experiment NA15510 vs. NA18505
We introduce high-throughput and massive paired-end mapping (PEM), a large-scale genome sequencing method to identify SVs 3 kb or larger that combines the rescue and capture of paired-ends of 3 kb fragments, massive 454 Sequencing, and a computational approach to map DNA reads onto a reference genom...
ORGANISM(S): Homo sapiens 
2007-09-28 | E-GEOD-9002 | biostudies-arrayexpress
UnknownGenome-wide and fine-resolution association analysis of malaria in West Africa.
Not available
S-EPMC2889040 | biostudies-literature
UnknownImpact of laparoscopic training, haptic feedback and visual haptic latency on virtual fine motor performance.
Not available
S-EPMC12432154 | biostudies-literature
UnknownPredictive genomic and transcriptomic analysis on endoscopic ultrasound-guided fine needle aspiration materials from primary pancreatic adenocarcinoma: a prospective multicentre study.
Not available
S-EPMC11497430 | biostudies-literature
TranscriptomicsSynergistic activation by p38MAPK and glucocorticoid signaling mediates induction of M2-like tumor-associated macrophages expressing the novel CD20 homolog MS4A8A.
Tumor-associated macrophages (TAMs) represent alternatively activated (M2) macrophages that support tumor growth. Previously, we have described a special LYVE-1(+) M2 TAM subset in vitro and in vivo; gene profiling of this TAM subset identified MS4A8A as a novel TAM molecule expressed in vivo by TAM...
ORGANISM(S): Mus musculus 
2012-05-22 | E-GEOD-38171 | biostudies-arrayexpress
UnknownFine mapping spatiotemporal mechanisms of genetic variants underlying cardiac traits and disease.
Not available
S-EPMC9975214 | biostudies-literature
UnknownDiscovery and fine mapping of serum protein loci through transethnic meta-analysis.
Not available
S-EPMC3484648 | biostudies-literature
UnknownMulti-ethnic fine-mapping of 14 central adiposity loci.
Not available
S-EPMC4119415 | biostudies-literature
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