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GenomicsThe Pdx1 Cistrome of Pancreatic Islets
We performed global location analysis of Pdx1 occupancy in mouse and human islets.
ORGANISM(S): Mus musculus 
2012-05-23 | E-MTAB-1143 | biostudies-arrayexpress
TranscriptomicsExpression Profiling Identifies Novel Gene Targets and Functions for Pdx1 in the Duodenum of Mature Mice
Transcription factor pancreatic and duodenal homeobox 1 (Pdx1) plays an essential role in the pancreas to regulate its development and maintain proper islet function. However, less is known about the function of Pdx1 in the small intestine. We aim to investigate the role of Pdx1 in mature proximal s...
ORGANISM(S): Mus musculus 
2012-01-12 | E-GEOD-29048 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of mouse MIN6 pancreatic beta cells to identify Pdx1 targets
The aim of this experiment was to use highthroughput chromatin immunoprecipitation followed by hybridization to promoter microarrays to obtain a comprehensive list of sites in the genome that are physically occupied by Pdx1. Chromatin was prepared from Min6 insulinoma cells and immunoprecipitated w...
ORGANISM(S): Mus musculus 
2009-12-02 | E-MTAB-134 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse wild type and Ipf1/Pdx1 null mutated pancreatic progenitor cells
Identification of differentially expressed genes in Ipf1/Pdx1 null mutated mouse pancreatic progenitor cells.
ORGANISM(S): Mus musculus 
2008-02-12 | E-TABM-280 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of the islets from Pdx1+/- mice compared to islets isolated from Pdx1 +/+ littermates
The aim of this experiment was to use global gene expression profiling to identify genes that are differentially expressed in the islets from Pdx1+/- mice compared to islets isolated from Pdx1 +/+ littermates. The Pdx1 null mutation consists of a nuclear targeted _-galactosidase cassette fused in-fr...
ORGANISM(S): Mus musculus 
2009-12-02 | E-MTAB-127 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of pancreatic buds from wild type and Ipf1/Pdx1 knock-out mouse embryos
Identification of genes regulated by IPF1/PDX1 in early pancreatic progenitor cells, analysis of Ipf1/Pdx1 global null mutants e10.5 embryonic pancreatic buds compared to wt
ORGANISM(S): Mus musculus 
2008-02-12 | E-MEXP-1047 | biostudies-arrayexpress
GenomicsPDX1 Binding in human embryonic stem cell derived pancreatic progenitor cells [ChIP-seq]
PDX1 binds and regulates numerous genes involved in human pancreatic development but also binds hepatic genes Examination of PDX1 regulated genes in pancreatic derived cell types
ORGANISM(S): Homo sapiens 
2014-06-21 | E-GEOD-58685 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse MIN6 insulinoma beta cells following knock-down of murine Pdx1
In order to identify genes that are regulated by Pdx1, MIN6 insulinoma cells were transduced with adenovirus expressing a short hairpin RNA directed against murine Pdx1 (AdshPdx1) or luciferase (AdshLuc) or not transduced at all (untreated). RNA was harvested and reverse transcribed. Reduced expre...
ORGANISM(S): Mus musculus 
2010-01-01 | E-MTAB-132 | biostudies-arrayexpress
TranscriptomicsExpression data from WT mice and bitransgenic Pdx1-cre/Kras*A mice bearing Pancreatic Ductal Adenocarcinoma
We have carried out transcriptional profile analysis in WT MICE and bitransgenic Pdx1-cre/Kras*A MICE baring Pancreatic Ductal Adenocarcinoma Mouse models faithfully simulating human cancer are valuable for genetic identification of potential drug-targets but, among them, the most advantageous for ...
ORGANISM(S): Mus musculus 
2014-09-01 | E-GEOD-53659 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of PDX1+ sub populations hESC-derived pancreatic endoderm cells and posterior foregut endoderm
The aim of the study was to define the specific gene expression signature of pancreatic endoderm cells (PECs), by designing a strategy for generating putative PECs (PDX1+/NKX6-1+, and posterior foregut endoderm (PFG) cells (PDX1+/NKX6-1-). Cell line: PDX1-eGFP reporter cell line (PDXeG clone 170-3...
ORGANISM(S): Homo sapiens 
2017-04-05 | E-MTAB-5088 | biostudies-arrayexpress
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