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TranscriptomicsRoquin promotes constitutive mRNA decay via a conserved class of stem-loop recognition motifs.
The degradation of TNFM-NM-1 mRNA is critical for restricting TNFM-NM-1 synthesis and involves a constitutive decay element (CDE) in the 3M-bM-^@M-^Y untranslated region of the mRNA. We demonstrate that the active CDE is a stem-loop RNA motif that is recognized by the RNA-binding protein Roquin. Dee...
ORGANISM(S): Mus musculus 
2013-05-15 | E-GEOD-44775 | biostudies-arrayexpress
UnknownIdentification of FLYWCH1 as a regulator of platinum-resistance in epithelial ovarian cancer.
Not available
S-EPMC11970373 | biostudies-literature
TranscriptomicsERRγ inhibition in Crls1KO C2C12
Knockdown of Crls1 results in mitochondrial dysfunction and muscle fiber type-specific adaptation processes both in vivo. Here, we identified the transcription factor ERRgamma as a crucial effector of those processes and we now aim to validate the importance in vitro using differentiated C2C12 myotu...
ORGANISM(S): Mus musculus 
2026-08-24 | E-MTAB-17526 | biostudies-arrayexpress
ProteomicsThe small heat shock protein Alpha-Crystallin B shows neuroprotective properties in a glaucoma animal model
Aim of this study was the evaluation of Alpha-crystallin B and its potential neuroprotective properties in an experimentalanimal model of glaucoma with subsequent analysis of possible altered downstream markers in a complex mass spectrometric approach.
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2017-11-28 | MSV000081755 | MassIVE
GenomicsSalt augments macrophage-driven host defense in the skin
Immune cells regulate a hypertonic microenvironment in the skin; however, possible functions of increased skin Na+ concentrations are unknown. We found that Na+ accumulated at the site of bacterial skin infections in humans and in mice. We used the protozoan parasite Leishmania (L.) major as a model...
ORGANISM(S): Mus musculus 
2015-02-26 | E-MTAB-3343 | biostudies-arrayexpress
TranscriptomicsMitochondrial carrier SLC25A34 links clock, diet, and temperature control of adipocyte lipid cycling
BAT transcriptome from control and brown adipocyte-specific Rev-erbα/β double knockout mice housed at thermoneutrality or cold-challenged for 6 hours. Brown adipose tissue (BAT) samples were collected from control and brown adipocyte-specific Rev-erbα/β double knockout mice (Ucp1-Cre; Nr1d1/2 fl/fl)...
ORGANISM(S): Mus musculus 
2026-09-23 | E-MTAB-17580 | biostudies-arrayexpress
TranscriptomicsMitochondrial carrier SLC25A34 links clock, diet, and temperature control of adipocyte lipid cycling
Transcriptome from immortalized murine brown adipocytes BMC. Cells were transfected with siRNA construct #1 or construct #2 (pool) or non-targeting control on day 3 of differentiation and harvested on day 7 of differentiation.
ORGANISM(S): Mus musculus 
2026-09-23 | E-MTAB-17577 | biostudies-arrayexpress
UnknownGrand Challenges in global eye health: a global prioritisation process using Delphi method.
Not available
S-EPMC8732284 | biostudies-literature
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