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TranscriptomicsAffymetrix SNP-array data for 2 ETV6/RUNX1-positive Acute Lymphoblastic Leukemia samples and corresponding normal samples
Acute lymphoblastic leukemia (ALL), the most common malignant disorder in childhood, is typically associated with numerical chromosomal aberrations, fusion genes or small focal deletions, thought to represent important pathogenetic events in the development of the leukemia. Mutations, such as single...
ORGANISM(S): Homo sapiens 
2012-07-02 | E-GEOD-25116 | biostudies-arrayexpress
TranscriptomicsIllumina SNP-array data for 2 ETV6/RUNX1-positive Acute Lymphoblastic Leukemia samples and corresponding normal samples
Acute lymphoblastic leukemia (ALL), the most common malignant disorder in childhood, is typically associated with numerical chromosomal aberrations, fusion genes or small focal deletions, thought to represent important pathogenetic events in the development of the leukemia. Mutations, such as single...
ORGANISM(S): Homo sapiens 
2012-07-02 | E-GEOD-25102 | biostudies-arrayexpress
TranscriptomicsAffy SNP-array data for 23 ETV6/RUNX1-positive ALL patient samples and one cell line
The ETV6/RUNX1 fusion gene, present in 25% of B-lineage childhood acute lymphoblastic leukemia (ALL), is thought to represent an initiating event, which requires additional genetic changes for leukemia development. To identify additional genetic alterations, 24 ETV6/RUNX1-positive ALLs were analyzed...
ORGANISM(S): Homo sapiens 
2010-07-07 | E-GEOD-19996 | biostudies-arrayexpress
TranscriptomicsZMYM2/FGFR1, BCR/FGFR1 or BCR/ABL1 in human cord blood CD34+ cells reveals similar but distinct gene expression profiles
The 8p11 myeloproliferative syndrome (EMS), also referred to as the stem cell leukemia/lymphoma syndrome, is a chronic myeloproliferative disorder that rapidly progresses into an acute leukemia. Molecularly, EMS is characterized by fusion of various partner genes to the FGFR1 gene, resulting in cons...
ORGANISM(S): Homo sapiens 
2010-05-27 | E-GEOD-15811 | biostudies-arrayexpress
TranscriptomicsLarge scale screening for known fusion genes in cancer cell lines
We have utilized a version 2.0 of our Fusion gene microarray (version 1.0 described by PMID: 19152679 and GEO, GPL8078) to screen cancer cell lines for known fusion genes We assembled a comprehensive database of published fusion genes, including those which have been reported only in individual stud...
ORGANISM(S): Homo sapiens 
2011-02-10 | E-GEOD-24737 | biostudies-arrayexpress
ProteomicsProteogenomics of High hyperdiploid childhood acute lymphoblastic leukemia
Proteogenomic analysis and genomic profiling, RNA-sequencing, and mass spectrometry-based analysis of High hyperdiploid childhood acute lymphoblastic leukemia.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-01-29 | MSV000084862 | MassIVE
TranscriptomicsEbf1 heterozygosity results in increased DNA damage in pro-B cells and their synergistic transformation by Pax5 haploinsufficiency
Ebf1 is a transcription factor with documented, and dose dependent, functions in both normal and malignant B-lymphocyte development. In order to understand more about the role of Ebf1 in malignant transformation, we have investigated the impact of reduced functional Ebf1 dose on early B-cell progeni...
ORGANISM(S): Mus musculus 
2015-03-31 | E-GEOD-67415 | biostudies-arrayexpress
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