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Aurora Kinase A (AURKA) is often overexpressed in neuroblastoma (NB) with poor outcome. The causes of AURKA overexpression in NB are unknown. Here, we describe a gene regulatory network consisting of core regulators of AURKA protein expression and activation during mitosis to identify potential caus...
We sequenced mRNA from 24 samples extracted from mouse CA1 tissue to generate the first CA1-specific murine transcriptome and the first CA1-transcriptome in response to environmental novelty under normal and Kat2a-loss-of-function conditions. Samples were divded in 4 groups: A: Control naM-CM-/ve (n...
ORGANISM(S): Mus musculus 
We sequenced small RNAs from 12 samples extracted from mouse CA1 tissue to generate the first CA1-specific murine miRNome under normal and Kat2a-loss-of-function conditions. Samples were divded in 4 groups: A: Control (n=6), C: Kat2a cKO naïve (n=6)
ORGANISM(S): Mus musculus 
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
This set of profiles was utilized to construct, validate and evaluate a gene-expression based classifier of outcome of neuroblastoma patients
ORGANISM(S): Homo sapiens 
mRNA-Seq of the CA1 hippocampal subregion from 3 month old animals injected with JQ1 (50mg/kg) i.p. and mRNA-Seq of CA1 of 8-10 month old APP/PS1-21 transgenic animals injected with JQ1 (50mg/kg) i.p.
This set of 320 profiles was utilized to construct, validate and evaluate a gene-expression based classifier of outcome of neuroblastoma patients
ORGANISM(S): Homo sapiens 
small RNA seq profile of DG and CA region of mice subjected to 2 or 10 weeks of environmental enrichment and their respective home cage controls
small RNA-Seq of the CA1 hippocampal subregion from 3 month and 20 month old animals treated orally with vehicle or SAHA
Genome-wide analysis of H4K12 acetylation in neuronal and non-neuronal nuclei in young animals treated with vehicle, WT littermates of APP/PS1-21 animals treated with vehicle and aged and APP/PS1-21 animals treated with oral vehicle or SAHA for 4 weeks
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