Kat2a regulates hippocampal memory formation [RNA-seq]
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Andre Fischer
PROVIDER: E-GEOD-53380 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
K-Lysine acetyltransferase 2a regulates a hippocampal gene expression network linked to memory formation.
Stilling Roman M RM Rönicke Raik R Benito Eva E Urbanke Hendrik H Capece Vincenzo V Burkhardt Susanne S Bahari-Javan Sanaz S Barth Jonas J Sananbenesi Farahnaz F Schütz Anna L AL Dyczkowski Jerzy J Martinez-Hernandez Ana A Kerimoglu Cemil C Dent Sharon Y R SY Bonn Stefan S Reymann Klaus G KG Fischer Andre A
The EMBO journal 20140714 17
Neuronal histone acetylation has been linked to memory consolidation, and targeting histone acetylation has emerged as a promising therapeutic strategy for neuropsychiatric diseases. However, the role of histone-modifying enzymes in the adult brain is still far from being understood. Here we use RNA sequencing to screen the levels of all known histone acetyltransferases (HATs) in the hippocampal CA1 region and find that K-acetyltransferase 2a (Kat2a)--a HAT that has not been studied for its role ...[more]
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