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GenomicsRegulating Interleukin-2 activity with engineered receptor signaling clamps
Interleukin-2 (IL-2) is a pleiotropic cytokine that regulates lymphocyte function by signaling through heterodimerization of the IL-2Rβ and γc receptor subunits. Previously, we engineered an IL-2 “superkine” (H9) with enhanced affinity for IL-2Rβ. Here, we describe next-generation IL-2 variants that...
ORGANISM(S): Homo sapiens 
2015-06-16 | E-GEOD-64713 | biostudies-arrayexpress
ProteomicsEicosadomics, proteomics and metabolomics of inflammatory stimulated human fibroblasts reveals specific functions related to chronic inflammation - secreted proteins of inflammatory stimulated cells
Fibroblasts have only recently been identified as important effector cells in inflammation. In this study, human dermal fibroblasts were inflammatory stimulated with interleukin-1beta and comprehensively analysed with respect to proteins, eicosanoids and metabolites. For eicosadomics, we have establ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-02 | MSV000080879 | MassIVE
ProteomicsEicosadomics, proteomics and metabolomics of inflammatory stimulated human fibroblasts reveals specific functions related to chronic inflammation - cytoplasmic proteins of dexamethasone-treated inflammatory stimulated cells
Fibroblasts have only recently been identified as important effector cells in inflammation. In this study, human dermal fibroblasts were inflammatory stimulated with interleukin-1beta and comprehensively analysed with respect to proteins, eicosanoids and metabolites. For eicosadomics, we have establ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-16 | MSV000080644 | MassIVE
ProteomicsEicosadomics, proteomics and metabolomics of inflammatory stimulated human fibroblasts reveals specific functions related to chronic inflammation - secreted proteins of untreated cells
Fibroblasts have only recently been identified as important effector cells in inflammation. In this study, human dermal fibroblasts were inflammatory stimulated with interleukin-1beta and comprehensively analysed with respect to proteins, eicosanoids and metabolites. For eicosadomics, we have establ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-16 | MSV000080642 | MassIVE
ProteomicsEicosadomics, proteomics and metabolomics of inflammatory stimulated human fibroblasts reveals specific functions related to chronic inflammation - secreted proteins of dexamethasone-treated inflammatory stimulated cells
Fibroblasts have only recently been identified as important effector cells in inflammation. In this study, human dermal fibroblasts were inflammatory stimulated with interleukin-1beta and comprehensively analysed with respect to proteins, eicosanoids and metabolites. For eicosadomics, we have establ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-16 | MSV000080640 | MassIVE
UnknownA double-blind, placebo-controlled trial assessing the efficacy of varenicline tartrate for alcohol dependence.
Not available
S-EPMC3914416 | biostudies-literature
TranscriptomicsCulture media-induced transcriptional variation in lung cancer (A549), colorectal cancer (HCT116), ovarium cancer (SKOV3) and glioblastoma (U87MG) spheroids
Spheroids, near spherical multicellular aggregates, are one of the most common types of threedimensional (3D) cell cultures. Despite decades of implementation of spheroid technology in various fields of life science and medical research, no minimal information (MI) guidelines are available to cope w...
ORGANISM(S): Homo sapiens 
2021-10-01 | E-MTAB-10862 | biostudies-arrayexpress
UnknownChronic kidney disease, cerebral blood flow, and white matter volume in hypertensive adults.
Not available
S-EPMC4818564 | biostudies-literature
UnknownFine-mapping of 150 breast cancer risk regions identifies 191 likely target genes.
Not available
S-EPMC6974400 | biostudies-literature
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