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MetabolomicsFecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...

2025-02-27 | MTBLS711 | MetaboLights
MetabolomicsGlobal ocean lipidomes show a universal relationship between temperature and lipid unsaturation

Global-scale surveys of plankton communities using “omics” techniques have revolutionized our understanding of the ocean. Lipidomics has demonstrated the potential to add further essential insights on ocean ecosystem function but has yet to be applied on a global scale. We analyzed 930 lipid samp...

2021-11-08 | MTBLS2838 | MetaboLights
MetabolomicsTwo apples a day modulate human:microbiome co-metabolic processing of polyphenols, tyrosine and tryptophan

PURPOSE: Validated biomarkers of food intake (BFIs) have recently been suggested as a useful tool to assess adherence to dietary guidelines or compliance in human dietary interventions. Although many new candidate biomarkers have emerged in the last decades for different foods fr...

2020-04-28 | MTBLS469 | MetaboLights
MetabolomicsLiquid chromatography coupled to high-resolution mass spectrometry metabolomics: A useful tool for investigating tumor secretome based on a three-dimensional co-culture model

Three-dimensional (3D) cell culture technologies, which more closely mimic the complex microenvironment of tissue, are being increasingly evaluated as a tool for the preclinical screening of clinically promising new molecules, and studying of tissue metabolism. Studies of metabolites released int...

2023-12-12 | MTBLS5375 | MetaboLights
ProteomicsSpring phytoplankton bloom in the North Sea during the 2020 spring bloom between 29th April and 11th May (sampling twice a day for 5th, 6th and 7th May 2020 at 7 AM and 9 PM)
The dataset represents the proteome analysis of eight sampling dates during the phytoplankton bloom at the island of Helgoland in the North Sea at the long-term research station ‘Kabeltonne’ (54˚11.3′N, 7˚54.0′E) in 2020. Samples for comparing short-term proteome dynamics were collected for three co...
ORGANISM(S): unclassified Bacteria (miscellaneous) 
2025-06-10 | PXD055396 | Pride
Metaproteomics Phytoplankton bloom 
MetabolomicsInvestigating the Mechanisms of Silver Nanoparticle Toxicity in Daphnia magna: A Multi-Omics Approach
Silver nanoparticles (AgNPs), one of the most common nanomaterials in use today, have been shown to enter the aquatic environment from use of commercially obtained products. Although acute toxicity has been shown in vitro and in vivo, there is still a great deal of uncertainty surrounding the molecu...
2017-05-08 | MTBLS260 | MetaboLights
TranscriptomicsPromiscuous RNA binding by PRC2
Polycomb repressive complex-2 (PRC2) is a histone methyltransferase required for epigenetic silencing during development and cancer. Long non-coding RNAs (lncRNAs) recruit PRC2 to chromatin, but the general role of RNA in maintaining repressed chromatin is unknown. ChIP-seq, combined with RNA-seq, i...
ORGANISM(S): Homo sapiens 
2013-09-28 | E-GEOD-50177 | biostudies-arrayexpress
MetabolomicsExploring Salivary Metabolites as Biomarkers in Chronic Craniofacial and Orofacial Pain: A Metabolomic Analysis.
Chronic facial pain (CFP) includes a range of conditions such as musculoskeletal, neurovascular, and neuropathic disorders affecting the facial and jaw regions, often causing significant distress to patients. This study aims to investigate the metabolomic profile of patients with CFP, focusing on sa...
2025-07-16 | MTBLS12704 | MetaboLights
TranscriptomicsListeria monocytogenes strain F2365 has reduced ability to survive stress while maintaining virulence characteristics
Listeria monocytogenes strain F2365 was the first strain representative of serotype 4b (lineage I) to be sequenced in 2004, suggesting it could become the model organism for this serotype, which is associated with most human outbreaks of listeriosis worldwide to date. F2365 itself is an outbreak st...
ORGANISM(S): Listeria monocytogenes 
2013-06-01 | E-GEOD-42730 | biostudies-arrayexpress
UnknownSimulations indicate that scores of lionfish (Pterois volitans) colonized the Atlantic Ocean.
Not available
S-EPMC5740958 | biostudies-literature
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