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MetabolomicsSCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia
Acute myeloid leukemia (AML) cells rely on phospho-signaling pathways to gain unlimited proliferation potential. Here, we used domain-focused CRISPR screening to identify the nuclear phosphatase SCP4 as a dependency in AML, yet this enzyme is dispensable in normal hematopoietic progenitor cells. Usi...
2025-05-29 | MTBLS3707 | MetaboLights
UnknownPhase II Intergroup Trial of Alisertib in Relapsed and Refractory Peripheral T-Cell Lymphoma and Transformed Mycosis Fungoides: SWOG 1108.
Not available
S-EPMC4500834 | biostudies-literature
TranscriptomicsModified iCLIP sequencing of HEK293 cells with antibody PTBP1
For modified iCLIP experiment, 4SU was used for crosslinking as described in published protocol (citation is bellow) and the RNase conditions were optimised to ensure efficient RNase I-dependent fragmentation. In detail, HEK293T cells were grown on 10 cm 2 dishes, incubated for 8 h with 100 M 4SU an...
ORGANISM(S): Homo sapiens 
2016-11-24 | E-MTAB-5027 | biostudies-arrayexpress
ProteomicsDesign, Implementation and Multisite Evaluation of a System Suitability Protocol for the Quantitative Assessment of Instrument Performance in Liquid Chromatography-Multiple Reaction Monitoring-MS (LC-MRM-MS)
Multiple reaction monitoring (MRM) mass spectrometry coupled with stable isotope dilution (SID) and liquid chromatography (LC) is increasingly used in biological and clinical studies for precise and reproducible quantification of peptides and proteins in complex sample matrices. Robust LC-SID-MRM-MS...
ORGANISM(S): Bos Taurus 
2018-07-23 | PXD010535 | panorama
ProteomicsA microenvironment-inspired synthetic 3D model for pancreatic ductal adenocarcinoma organoids - IAC Sets
Integrin adhesion complex (IAC) datasets from KPC-1 and iKRAS cells after 3h or 12h of adhesion on a fibronectin pre-coated surface. IACs were isolated using previously established methods and IACs were investigated using LC-MS/MS.
ORGANISM(S): Mus musculus (Mouse) 
2021-11-29 | PXD022487 | Pride
Tumour Organoids Syntheticmatrice Pdac 
ProteomicsA microenvironment-inspired synthetic 3D model for pancreatic ductal adenocarcinoma organoids - 3D PEG-CBF-0.5 MS
LC-MS/MS based analysis of murine PCOs growing in 3D PEG-CBF-0.5 hydrogels for four days.
ORGANISM(S): Mus musculus (Mouse) 
2021-11-29 | PXD022520 | Pride
Ecm Pdac Organoids Syntheticmatrix 
ProteomicsA microenvironment-inspired synthetic 3D model for pancreatic ductal adenocarcinoma organoids - CDM Sets
Cell-derived matrix (CDM) datasets from KPC-1 or HPDE cells after seven days of growth.
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-11-29 | PXD022509 | Pride
Ecm Pdac Cancer Syntheticmatrix 
UnknownRelationship Between Severity of Ischemia and Coronary Artery Disease for Different Stress Test Modalities in the ISCHEMIA Trial.
Not available
S-EPMC11658795 | biostudies-literature
ProteomicsA pipeline that integrates the discovery and verification of plasma protein biomarkers reveals candidate markers for cardiovascular disease
Addona TA, Shi X, Keshishian H, Mani DR, Burgess M, Gillette MA, Clauser KR, Shen D, Lewis GD, Farrell LA, Fifer MA, Sabatine MS, Gerszten RE, Carr SA. Nat Biotechnol. 2011, 29(7):635-43. doi: 10.1038/nbt.1899. PMCID:PMC3366591. Discovery, AIMS, and MRM datasets Discovery_Tranche_hash: b/quYtp/Q8fY...
2013-12-19 | MSV000078513 | MassIVE
UnknownDYRK1A pathogenic variants in two patients with syndromic intellectual disability and a review of the literature.
Not available
S-EPMC7767569 | biostudies-literature
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