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MetabolomicsVeterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs (T. congolense assay)

Livestock diseases caused by Trypanosoma congolense, T. vivax and T. brucei, collectively known as nagana, are responsible for billions of dollars in lost food production annually. There is an urgent need for novel therapeutics. Encouragingly, promising antitrypanosomal benzoxaboroles are under v...

2020-10-22 | MTBLS1309 | MetaboLights
MetabolomicsMetabolic adaptation of diatoms to hypersalinity

Microalgae are important primary producers and form the basis for the marine food web. As global climate changes, so do salinity levels that algae are exposed to. A metabolic response of algal cells partly alleviates the resulting osmotic stress. Some metabolites involved in the response are well...

2023-09-04 | MTBLS3177 | MetaboLights
TranscriptomicsNF-κB target gene microarray in HAECs in response to Pseudomonas aeruginosa
An NF-κB target gene array (Panomics, Inc., Redwood City, CA) was performed to profile the PAO1-dependent expression pattern of 111 NF-kB-regulated genes in primary human airway epithelial cells (HAECs). A small scale microarray was carried out using NF-κB target gene array kit (Panomics, Inc., Redw...
ORGANISM(S): Homo sapiens 
2007-09-08 | E-GEOD-8986 | biostudies-arrayexpress
ProteomicsKi-67 organises heterochromatin during cell proliferation
Antigen Ki-67 is a nuclear protein expressed in proliferating mammalian cells. It is widely used in cancer histopathology but its functions remain unclear. Here, we show that Ki-67 controls heterochromatin organisation. Altering Ki-67 expression levels did not significantly affect cell proliferation...
ORGANISM(S): Homo sapiens (Human) 
2018-10-26 | PXD003551 | Pride
Ki-67 interactome Cell proliferation Heterochromatin Mki67 Antigen ki-67 
MetabolomicsNPC1 regulates the distribution of phosphatidylinositol 4 kinases at Golgi and Lysosome membranes
Cholesterol and phosphoinositides (PI) are two critically important lipids that are found in cellular membranes and dysregulated in many disorders. Therefore, uncovering molecular pathways connecting these essential lipids may offer new therapeutic insights. We report that loss of function of lysoso...
2021-09-15 | MTBLS2612 | MetaboLights
ProteomicsHistone H3 Serine-57 phosphorylation by CHK1 promotes responses to DNA replication stress
Post-translational modifications (PTM) of chromatin control the genomic environment for transcription, DNA replication and repair in response to cell stimuli1–3. Replication stress in budding and fission yeasts leads to abundant acetylation of histone H3 on lysine-56 (H3K56ac)4–6, but only trace lev...
ORGANISM(S): Homo sapiens (Human) Xenopus laevis (African clawed frog) 
2022-02-10 | PXD011328 | Pride
Histone post-translational modifications H3s57ph Checkpoint kinase 1 (chk1) Chromatin Dna replication stress 
TranscriptomicsCpG site methylation of HCV-cirrhotic, HCV-HCC, and normal liver tissues
In this study we used a high-throughput method for assaying methylation of CpG sites simultaneously in a single sample for identifying differences in methylation observed in tissues ranging from normal liver to pre-neoplastic (cirrhosis) and neoplastic (HCC) states. Since there are important clinica...
ORGANISM(S): Homo sapiens 
2010-02-18 | E-GEOD-18081 | biostudies-arrayexpress
UnknownTransition from static culture to stirred tank bioreactor for the allogeneic production of therapeutic discogenic cell spheres.
Not available
S-EPMC8359559 | biostudies-literature
MetabolomicsComparison of singlequad and Orbitrap mass analyzer coupled to gas chromatography reveals potential of high resolution GC MS for untargeted metabolomics

The development of improved spectrometers and supporting computational tools is expected to eventually enable the rapid annotation of whole metabolomes. However, rarely are novel mass spectrometers directly compared to the previously used ones in the field of metabolomics, thus preventing researc...

2020-01-24 | MTBLS1104 | MetaboLights
MetabolomicsStrong effect of Penicillium roqueforti populations on volatile and metabolic compounds responsible for aromas, flavour and texture in blue cheeses
Studies of food microorganism domestication can provide important insight into adaptation mechanisms and lead to commercial applications. Penicillium roqueforti is a fungus with four genetically differentiated populations, two of which were independently domesticated for blue cheese-making, with the...
2021-10-06 | MTBLS1509 | MetaboLights
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