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ProteomicsHistone H3 Serine-57 phosphorylation by CHK1 promotes responses to DNA replication stress
Post-translational modifications (PTM) of chromatin control the genomic environment for transcription, DNA replication and repair in response to cell stimuli1–3. Replication stress in budding and fission yeasts leads to abundant acetylation of histone H3 on lysine-56 (H3K56ac)4–6, but only trace lev...
ORGANISM(S): Homo sapiens (Human) Xenopus laevis (African clawed frog) 
2022-02-10 | PXD011328 | Pride
Histone post-translational modifications H3s57ph Checkpoint kinase 1 (chk1) Chromatin Dna replication stress 
GenomicsGenome-wide localisation of histone H3S57ph in proliferating and hydroxyurea pre-treated cells
Genome-wide localisation of histone H3S57ph in proliferating and hydroxyurea pre-treated cells
PRJNA490171 | ENA
UnknownHistone H3 serine-57 is a CHK1 substrate whose phosphorylation affects DNA repair.
Not available
S-EPMC10444856 | biostudies-literature
GenomicsGenome-wide localisation of histone H3S57ph in proliferating and hydroxyurea pre-treated cells
We identified a species of histone H3 phosphorylated on serine 57 and showed that it is involved in responses to DNA replication stress. Here we asked whether it is specifically localised in the human genome by ChIP-seq from human osteosarcoma cells (U2OS) growing exponentially or treated with 2mM h...
ORGANISM(S): Homo sapiens 
2019-12-31 | GSE119742 | GEO
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