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ProteomicsPatient-derived anti-Siglec-6 antibodies engineered into T cell-recruiting bispecific antibody formats for treating leukemia
Despite numerous therapeutic options, safe and curative therapy is out of reach for most chronic lymphocytic leukemia (CLL) patients. We previously reported the identification of a patient-derived CLL-binding antibody, JML-1, and identified Siglec-6 as the target of JML-1. Siglec-6 is an attractive ...
ORGANISM(S): Homo sapiens (Human) 
2022-12-19 | PXD029601 | Pride
Siglec-6 Antibody Hdx-ms 
TranscriptomicsRNA-seq of blood from donors with connective tissue diseases in the Lupus Extended Phenotype Cohort
The connective tissue diseases (CTDs) are group of inflammatory disorders with overlapping clinical and serological manifestations. We have undertaken Lupus Extended Phenotype (LEAP) study in of a cohort of adult patients with CTDs, namely systemic lupus erythematosus, Sjogren's syndrome, mixed and ...
ORGANISM(S): Homo sapiens 
2019-06-05 | E-MTAB-7080 | biostudies-arrayexpress
TranscriptomicsTrichuris muris infection drives cell-intrinsic IL4R alpha independent large intestinal RELMα+ macrophages.
The RELMα+ macrophage phenotype associates with the presence of anti-inflammatory macrophages and work in other model systems has demonstrated that the balance of pro-inflammatory and anti-inflammatory macrophages is critically important in enabling the resolution of inflammation. Moreover, in the c...
ORGANISM(S): Mus musculus 
2021-11-15 | E-MTAB-10501 | biostudies-arrayexpress
UnknownEarly GFAP and UCH-L1 point-of-care biomarker measurements for the prediction of traumatic brain injury and progression in patients with polytrauma and hemorrhagic shock.
Not available
S-EPMC11174922 | biostudies-literature
UnknownVaccine Effectiveness Against Influenza A-Associated Hospitalization, Organ Failure, and Death: United States, 2022-2023.
Not available
S-EPMC11487098 | biostudies-literature
UnknownRheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13.
Not available
S-EPMC2662493 | biostudies-literature
UnknownRisk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.
Not available
S-EPMC6306365 | biostudies-literature
UnknownEffect of Thromboprophylaxis on Clinical Outcomes After COVID-19 Hospitalization.
Not available
S-EPMC10064277 | biostudies-literature
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