Sort   by:  
 Page size 
ProteomicsPatient-derived anti-Siglec-6 antibodies engineered into T cell-recruiting bispecific antibody formats for treating leukemia
Despite numerous therapeutic options, safe and curative therapy is out of reach for most chronic lymphocytic leukemia (CLL) patients. We previously reported the identification of a patient-derived CLL-binding antibody, JML-1, and identified Siglec-6 as the target of JML-1. Siglec-6 is an attractive ...
ORGANISM(S): Homo sapiens (Human) 
2022-12-19 | PXD029601 | Pride
Siglec-6 Antibody Hdx-ms 
ProteomicsIdentification of proteins that interact with Siglec-6
Siglec-6 is a glycoprotein overexpressed on chronic lymphocytic leukemia (CLL) cell. We have shown that Siglec-6 promotes migration and adhesion of CLL cells towards CLL bone marrow stromal cells. To elucidate the mechanistic pathway involved in Siglec-6 dependent migration, we performed mass spectr...
ORGANISM(S): Homo sapiens (Human) 
2024-05-08 | PXD039892 | Pride
Human Cell migration Chronic lymphocytic leukemia 
TranscriptomicsSevere Preeclampsia-Related Changes in Gene Expression at the Maternal-Fetal Interface Include Siglec-6 and Pappalysin-2
Preeclampsia (PE), which affects 4-8% of human pregnancies, causes significant maternal and neonatal morbidity and mortality. Within the basal plate, placental cytotrophoblasts (CTBs) of fetal origin invade the uterus and extensively remodel the maternal vasculature. In PE, CTB invasion is often sha...
ORGANISM(S): Homo sapiens 
2009-02-06 | E-GEOD-14722 | biostudies-arrayexpress
GenomicsUpregulation of Siglec-6 induces mitochondrial dysfunction by promoting GPR20 expression in early-onset preeclampsia
Upregulation of Siglec-6 induces mitochondrial dysfunction by promoting GPR20 expression in early-onset preeclampsia
PRJNA1036233 | ENA
TranscriptomicsUpregulation of Siglec-6 induces mitochondrial dysfunction by promoting GPR20 expression in early-onset preeclampsia
Preeclampsia (PE) is a pregnancy complication that seriously threatens maternal and fetal health, but its pathogenesis is unclear. A growing number of studies have revealed significant changes in the mitochondria of placental trophoblasts in PE, with abnormalities in mitochondrial content, morpholog...
ORGANISM(S): Homo sapiens 
2025-12-31 | GSE247109 | GEO
UnknownFunctional and Phenotypic Characterization of Siglec-6 on Human Mast Cells.
Not available
S-EPMC8997871 | biostudies-literature
UnknownFunctional Inhibitory Siglec-6 Is Upregulated in Human Colorectal Cancer-Associated Mast Cells.
Not available
S-EPMC6159741 | biostudies-literature
UnknownSiglec-6 mediates the uptake of extracellular vesicles through a noncanonical glycolipid binding pocket.
Not available
S-EPMC10122656 | biostudies-literature
UnknownDiscovery of an agonistic Siglec-6 antibody that inhibits and reduces human mast cells.
Not available
S-EPMC9652399 | biostudies-literature
UnknownSiglec-6 as a therapeutic target for cell migration and adhesion in chronic lymphocytic leukemia.
Not available
S-EPMC11189495 | biostudies-literature
Sort   by:  
 Page size