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MetabolomicsA metabolomic study of adipose tissue in mice with a disruption of the circadian system

Adipose tissue functions in terms of energy homeostasis as a rheostat for blood triglyceride, regulating its concentration, in response to external stimuli. In addition it acts as a barometer to inform the central nervous system of energy levels which can vary dramatically between meals and accor...

2017-10-27 | MTBLS390 | MetaboLights
MetabolomicsA Pilot Characterization of the Human Chronobiome
Physiological function, disease expression and drug effects vary by time-of-day. Clock disruption in mice results in cardio-metabolic, immunological and neurological dysfunction; circadian misalignment using forced desynchrony increases cardiovascular risk factors in humans. Here we integrated data ...
2018-05-16 | MTBLS656 | MetaboLights
ProteomicsMass spectrometry to identify RNA binding proteins interacting with PACERR RNA
Protein lysates NE-PER Nuclear and Cytoplasmic Extraction Reagents (Thermo Scientific 78833) was used to isolate nuclear proteins from THP-1 macrophages. In vitro transcribed RNA PACERR cloned into pGEM-7Z+ (Promega P2251) was the template to in vitro-transcribe RNA using T7 RNA polymerase, and b...
ORGANISM(S): Homo sapiens (Human) 
2026-08-13 | PXD082116 | Pride
Mass spectrometery Proteomics Pacerr 
MetabolomicsCyclooxygenase-2, Asymmetric Dimethylarginine, and the Cardiovascular Hazard From Nonsteroidal Anti-Inflammatory Drugs (Murine kidney and plasma UPLC-MS/MS assay)

BACKGROUND: Large-scale, placebo-controlled trials established that nonsteroidal anti-inflammatory drugs confer a cardiovascular hazard: this has been attributed to depression of cardioprotective products of cyclooxygenase (COX)-2, especially prostacyclin. An alternative mechanis...

2019-08-22 | MTBLS680 | MetaboLights
UnknownAspirin in Hepatocellular Carcinoma.
Not available
S-EPMC8286305 | biostudies-literature
MetabolomicsCyclooxygenase-2, Asymmetric Dimethylarginine, and the Cardiovascular Hazard From Nonsteroidal Anti-Inflammatory Drugs (Murine and human plasma quantitative L-arginine and methylarginines UPLC-MS/MS assay)

BACKGROUND: Large-scale, placebo-controlled trials established that nonsteroidal anti-inflammatory drugs confer a cardiovascular hazard: this has been attributed to depression of cardioprotective products of cyclooxygenase (COX)-2, especially prostacyclin. An alternative mechanis...

2019-08-22 | MTBLS685 | MetaboLights
UnknownNanotherapeutic-directed approaches to analgesia.
Not available
S-EPMC8195851 | biostudies-literature
UnknownNonsteroidal anti-inflammatory drugs and glucocorticoids in COVID-19.
Not available
S-EPMC8280659 | biostudies-literature
UnknownLipocalin-Like Prostaglandin D Synthase but Not Hemopoietic Prostaglandin D Synthase Deletion Causes Hypertension and Accelerates Thrombogenesis in Mice.
Not available
S-EPMC6226547 | biostudies-literature
UnknownTargeted delivery of mPGES-1 inhibitors to macrophages via the folate receptor-β for inflammatory pain.
Not available
S-EPMC8484072 | biostudies-literature
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