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ProteomicsMass spectrometry to identify RNA binding proteins interacting with PACERR RNA
Protein lysates NE-PER Nuclear and Cytoplasmic Extraction Reagents (Thermo Scientific 78833) was used to isolate nuclear proteins from THP-1 macrophages. In vitro transcribed RNA PACERR cloned into pGEM-7Z+ (Promega P2251) was the template to in vitro-transcribe RNA using T7 RNA polymerase, and b...
ORGANISM(S): Homo sapiens (Human) 
2026-08-13 | PXD082116 | Pride
Mass spectrometery Proteomics Pacerr 
TranscriptomicsThe regulation of COX-2, ABCA1 and ABCG1 by the lncRNA PACERR links the inflammatory response and cholesterol homeostasis
The COX-2 antisense lncRNA PACERR interacts with discrete RNA binding proteins to mediate a cell specific COX-2 response to HDL. PACERR exerts its action both in cis and in trans, controlling the expression of COX-2 in macrophages, while also regulating the levels of macrophage ABCA1 and ABCG1, chol...
ORGANISM(S): Homo sapiens 
2026-07-20 | GSE328984 | GEO
GenomicsThe regulation of COX-2, ABCA1 and ABCG1 by the lncRNA PACERR links the inflammatory response and cholesterol homeostasis
The regulation of COX-2, ABCA1 and ABCG1 by the lncRNA PACERR links the inflammatory response and cholesterol homeostasis
PRJNA1457316 | ENA
UnknownLncRNA-PACERR induces pro-tumour macrophages via interacting with miR-671-3p and m6A-reader IGF2BP2 in pancreatic ductal adenocarcinoma.
Not available
S-EPMC9077921 | biostudies-literature
TranscriptomicsThe CTCF/LncRNA-PACERR/EP300 complex in TAMs promotes the malignant progression of pancreatic ductal adenocarcinoma (PDAC) by docking at the PTGS2 promoter region
The unregulated expression of COX-2 in tams is causally related to the occurrence, development and outcome of pancreatic ductal adenocarcinoma. We describe a new basic level of transcriptional control of COX-2 expression. Constructing in vivo and in vitro TAM model lines, we found that CTCF plays a ...
ORGANISM(S): Homo sapiens 
2021-06-30 | GSE169451 | GEO
GenomicsThe CTCF/LncRNA-PACERR/EP300 complex in TAMs promotes the malignant progression of pancreatic ductal adenocarcinoma (PDAC) by docking at the PTGS2 promoter region
The CTCF/LncRNA-PACERR/EP300 complex in TAMs promotes the malignant progression of pancreatic ductal adenocarcinoma (PDAC) by docking at the PTGS2 promoter region
PRJNA716651 | ENA
UnknownThe CTCF/LncRNA-PACERR complex recruits E1A binding protein p300 to induce pro-tumour macrophages in pancreatic ductal adenocarcinoma via directly regulating PTGS2 expression.
Not available
S-EPMC8858628 | biostudies-literature
UnknownIdentification and verification of a prognostic ferroptosis-related lncRNAs signature for patients with lung adenocarcinoma.
Not available
S-EPMC9274545 | biostudies-literature
UnknownIntegrative analysis of long non-coding RNA and messenger RNA expression in toll-like receptor 4-primed mesenchymal stem cells of ankylosing spondylitis.
Not available
S-EPMC8576702 | biostudies-literature
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