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TranscriptomicsRescue Of Dysfunctional Autophagy By Peptide IDR-1018 Attenuates Hyperinflammatory Phenotype Of Cystic Fibrosis Cells (RNA-seq)
Genome-wide gene expression was measured in peripheral blood mononuclear cells (PBMCs) from patients with cystic fibrosis (CF) after treatment in vitro with the flagellin protein fliC, and/or synthetic peptide IDR-1018 to assess patterns of gene expression. The patterns of gene expression suggest th...
ORGANISM(S): Homo sapiens 
2012-11-20 | E-GEOD-35394 | biostudies-arrayexpress
TranscriptomicsSynthetic cationic peptide IDR-1018 modulates human macrophage differentiation
Synthetic, innate defense regulators (IDR) peptides, designed based on natural host defenses peptides, have enhanced immunomodulatory activities and reduced toxicity leading to protection in infection and inflammation models that is dependent on macrophages/monocytes. Here we measured the effect of ...
ORGANISM(S): Homo sapiens 
2013-10-16 | E-GEOD-40131 | biostudies-arrayexpress
TranscriptomicsRescue Of Dysfunctional Autophagy By Peptide IDR-1018 Attenuates Hyperinflammatory Phenotype Of Cystic Fibrosis Cells
Genome-wide gene expression was measured in two cell lines: CF bronchial epithelial cell line IB3-1 (compound heterozygote for the ΔF508 and W1282X CFTR mutations) and the isogenic, CFTR-corrected C38 cell line, after treatment with the flagellin protein FliC, and/or synthetic peptide IDR-1018. Tota...
ORGANISM(S): Homo sapiens 
2012-11-05 | E-GEOD-35391 | biostudies-arrayexpress
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