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TranscriptomicsGene expression profiles of HCT116 colorectal carcinoma cells treated with HDAC inhibitors
Histone deacetylases (HDACs) regulate gene expression. Inhibition of class I HDACs has been shown to inhibit cancer cell growth. Largazole, a new potent HDAC inhibitor, shows strong antitumor activity, presumably by modulating transcription of cancer relevant genes. We used microarray analysis of hu...
ORGANISM(S): Homo sapiens 
2010-08-28 | E-GEOD-22061 | biostudies-arrayexpress
GenomicsCompare the transcriptomic effects of FK228 and Class I HDACs YF mutants overexpression
Compare the transcriptomic effects of FK228 and Class I HDACs YF mutants overexpression
PRJNA1154675 | ENA
TranscriptomicsCompare the transcriptomic effects of FK228 and Class I HDACs YF mutants overexpression
To compare the transcriptomic effects of FK228 and Class I HDACs YF mutants overexpression and to characterize their inter-dependency, we performed RNA-seq in AML12 cells in the above-mentioned 4 groups: control, FK228, YF overexpression, and FK228 + YF overexpression.
ORGANISM(S): Mus musculus 
2026-03-28 | GSE276094 | GEO
GenomicsCompare the loci-specific histone acetylation on the chromatin of FK228 and Class I HDACs YF mutants overexpression
Compare the loci-specific histone acetylation on the chromatin of FK228 and Class I HDACs YF mutants overexpression
PRJNA1156000 | ENA
UnknownFK228 from Burkholderia thailandensis MSMB43.
Not available
S-EPMC3435793 | biostudies-literature
GenomicsCompare the loci-specific histone acetylation on the chromatin of FK228 and Class I HDACs YF mutants overexpression
To compare the H3K27ac effects of FK228 and Class I HDACs YF mutants overexpression and to characterize their inter-dependency, we performed ChIP-seq in AML12 cells in the above-mentioned 4 groups: control, FK228, YF overexpression, and FK228 + YF overexpression.
ORGANISM(S): Mus musculus 
2026-03-28 | GSE276219 | GEO
UnknownFK228 reshapes tumor microenvironment to enhance anti-PD-L1 efficacy.
Not available
S-EPMC12454147 | biostudies-literature
UnknownFK228 sensitizes radioresistant small cell lung cancer cells to radiation.
Not available
S-EPMC7905898 | biostudies-literature
UnknownGenomics-guided discovery of a new and significantly better source of anticancer natural drug FK228.
Not available
S-EPMC6222137 | biostudies-literature
UnknownSynthesis and conformation-activity relationships of the peptide isosteres of FK228 and largazole.
Not available
S-EPMC2880701 | biostudies-literature
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