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ProteomicsThe role of FKBP51 in the activation of Akt oncogenic pathway
FKBP51 is an immunophilin with a relevant role in sustaining cancer cell growth and aggressiveness, particularly in melanoma. Thanks to its scaffold and isomerase activities, mediated by its TPR and FK1 domains, respectively, FKBP51 participates in several signaling pathways. Akt is a serine-threoni...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD033828 | Pride
Lc-ms-ms Fkbp51 Interactome 
TranscriptomicsAlzheimer's Disease Dataset
FK506 binding protein 51kDa (FKBP51/FKBP5) is part of a mature heat shock protein 90kDa (Hsp90) chaperone complex that preserves tau. Microarray analysis of human brains reveal that FKBP51 gene expression selectively increased with age and Alzheimer's disease, which correlated with demethylation of ...
ORGANISM(S): Homo sapiens 
2014-04-21 | E-GEOD-48350 | biostudies-arrayexpress
GenomicsEffects of FKBP51-Hsp90 PPI inhibitors on obese mice
Effects of FKBP51-Hsp90 interaction inhibitors on high-fat diet-induced obese mice
PRJEB53550 | ENA
GenomicsPharmacological inhibition of FKBP51 mitigates early life adversity-induced social deficits
Pharmacological inhibition of FKBP51 mitigates early life adversity-induced social deficits
PRJNA1416346 | ENA
UnknownThe Many Faces of FKBP51.
Not available
S-EPMC6359276 | biostudies-literature
TranscriptomicsPharmacological inhibition of FKBP51 mitigates early life adversity-induced social deficits
Early life adversity (ELA) is a major risk factor for psychiatric disorders, but targeted preventative strategies are lacking due to poor mechanistic insight. The FKBP51 protein, a co-chaperone of the glucocorticoid receptor, is a key mediator of stress vulnerability. We tested if pharmacological in...
ORGANISM(S): Mus musculus 
2026-07-15 | GSE318028 | GEO
GenomicsFKBP51 in glutamatergic forebrain neurons promotes early life stress inoculation in female mice via a Tcf4-mediated pathway
FKBP51 in glutamatergic forebrain neurons promotes early life stress inoculation in female mice via a Tcf4-mediated pathway
PRJNA1079744 | ENA
GenomicsSex-Specific and Opposed Effects of FKBP51 in Glutamatergic and GABAergic Neurons: Implications for Stress Susceptibility and Resilience
Sex-Specific and Opposed Effects of FKBP51 in Glutamatergic and GABAergic Neurons: Implications for Stress Susceptibility and Resilience
PRJNA972070 | ENA
UnknownFKBP51 regulates cell motility and invasion via RhoA signaling.
Not available
S-EPMC5378274 | biostudies-literature
TranscriptomicsSex-Specific and Opposed Effects of FKBP51 in Glutamatergic and GABAergic Neurons: Implications for Stress Susceptibility and Resilience
Mental health disorders often arise as a combination of environmental and genetic factors. The FKBP5 gene, encoding the GR co-chaperone FKBP51, has been uncovered as a key genetic risk factor for stress related illness. However, the exact cell type and region-specific mechanisms by which FKBP51 cont...
ORGANISM(S): Mus musculus 
2023-05-16 | GSE232460 | GEO
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