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MetabolomicsFatty acid oxidation protects cancer cells from apoptosis through increasing mitochondrial membrane lipids

Overcoming resistance to chemotherapies remains a major unmet need for cancers such as triple negative breast cancer (TNBC). Therefore, mechanistic studies to provide insight for drug development are urgently needed to overcome TNBC therapy resistance. Recently, an important role of fatty acid β-...

2022-05-31 | MTBLS4709 | MetaboLights
ProteomicsThe Flash Oxidation (FOX) System: A Novel Laser-free Fast Photochemical Oxidation Protein Footprinting Platform
To validate the FOX flash photolysis system for hydroxyl radical footprinting of proteins experiments, TNF-alpha was oxidized in the presence and absence of a specific monoclonal antibody, adalimumab. The peptides that show decrease in oxidation correlate well with the known epitope for adalimumab.
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD023169 | Pride
Flash photolysis Hrpf Tumor necrosis factor-alpha Mass spectrometry Fpop 
MetabolomicsER stress inhibits liver fatty acid oxidation while unmitigated stress leads to anorexia-induced lipolysis and both liver and kidney steatosis
The unfolded protein response (UPR), induced by endoplasmic reticulum (ER) stress, regulates the expression of factors that restore protein folding homeostasis. However, in the liver and kidney, ER stress also leads to lipid accumulation, accompanied at least in the liver by transcriptional suppress...
2017-06-23 | MTBLS472 | MetaboLights
ProteomicsStructural Analysis of Phosphorylation Proteoforms in a Dynamic Heterogeneous System Using Flash Oxidation Coupled In-Line with Ion Exchange Chromatography
Protein post-translational modifications (PTMs) are key modulators of protein structure and function that often change in a dynamic fashion in response to cellular stimuli. Dynamic post-translational modifications are very challenging to structurally characterize using modern techniques, including c...
ORGANISM(S): Gallus gallus (Chicken) 
2023-01-16 | PXD037050 | Pride
Flash oxidation Ovalbumin Phosphoproteoforms Lc-fox 
ProteomicsInline liquid chromatography- Flash oxidation for structural analysis of non-stoichiometric protein-ligand interaction
Size exclusion chromatography coupled to a flash oxidation unit from GenNext technologies was used to perform fast photochemical oxidation of proteins of human antithrombin III (ATIII) in the presence of unfractionated heparin. The footprint was calculated for the ATIII alone and ATIII bound to unfr...
ORGANISM(S): Homo sapiens (Human) Acyrthosiphon pisum (Pea aphid) 
2026-02-02 | PXD034906 | Pride
Hrpf Fpop Lc-fpop 
UnknownFlash Oxidation (FOX) System: A Novel Laser-Free Fast Photochemical Oxidation Protein Footprinting Platform.
Not available
S-EPMC8812269 | biostudies-literature
UnknownSensitized Photo-Oxidation of Anserine and Carnosine: Laser Flash Photolysis and CIDNP Study.
Not available
S-EPMC12670311 | biostudies-literature
UnknownStructural Analysis of Phosphorylation Proteoforms in a Dynamic Heterogeneous System Using Flash Oxidation Coupled In-Line with Ion Exchange Chromatography.
Not available
S-EPMC9912381 | biostudies-literature
ProteomicsMultiple Proteases to Localize Oxidation Sites
Proteins present in cellular environments with high levels of reactive oxygen and nitrogen species and/or low levels of antioxidants are highly susceptible to oxidative post-translational modification (PTM). Irreversible oxidative PTMs can generate a complex distribution of modified protein molecul...
ORGANISM(S): Bos taurus (Bovine) 
2016-07-06 | PXD001204 | Pride
Orbitrap mass spectrometry Bottom-up proteomics Oxidation Top-down Ubiquitin 
UnknownEarly Events of Photosensitized Oxidation of Sulfur-Containing Amino Acids Studied by Laser Flash Photolysis and Mass Spectrometry.
Not available
S-EPMC7498160 | biostudies-literature
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