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ProteomicsStructural Analysis of Phosphorylation Proteoforms in a Dynamic Heterogeneous System Using Flash Oxidation Coupled In-Line with Ion Exchange Chromatography
Protein post-translational modifications (PTMs) are key modulators of protein structure and function that often change in a dynamic fashion in response to cellular stimuli. Dynamic post-translational modifications are very challenging to structurally characterize using modern techniques, including c...
ORGANISM(S): Gallus gallus (Chicken) 
2023-01-16 | PXD037050 | Pride
Flash oxidation Ovalbumin Phosphoproteoforms Lc-fox 
ProteomicsQuantitative Top-Down Proteomics Revealed Staurosporine-induced Proteoform-level Changes in Cancer Cells
We conducted a quantitative top-down proteomics analysis on HeLa cells treated with staurosporine to investigate differential expression of proteoforms. Furthermore, we assessed alterations in phosphorylation patterns for intact phosphoproteoforms
ORGANISM(S): Homo sapiens (Human) 
2025-01-31 | PXD048148 | Pride
Proteomics Hela Phosphorylation Quantitative Top-down Staurosporine 
UnknownPrecise Readout of MEK1 Proteoforms upon MAPK Pathway Modulation by Individual Ion Mass Spectrometry.
Not available
S-EPMC11008683 | biostudies-literature
UnknownStructural Analysis of Phosphorylation Proteoforms in a Dynamic Heterogeneous System Using Flash Oxidation Coupled In-Line with Ion Exchange Chromatography.
Not available
S-EPMC9912381 | biostudies-literature
UnknownComprehensive Characterization of the Recombinant Catalytic Subunit of cAMP-Dependent Protein Kinase by Top-Down Mass Spectrometry.
Not available
S-EPMC6922056 | biostudies-literature
ProteomicsProtein ‘Purity’, Proteoforms, and the Albuminome: Critical Observations on Proteome and Systems Complexity
The identification of effective, selective biomarkers and therapeutics is dependent on truly deep, comprehensive analysis of proteomes at the proteoform level. Using bovine serum albumin (BSA) isolated by two different protocols, cold ethanol fractionation (CEF) and heat shock fractionation (HSF), t...
ORGANISM(S): Bos taurus (Bovine) 
2024-12-07 | PXD056316 | Pride
Proteoforms Therapeutics Two-dimensional gel electrophoresis Tandem mass spectrometry Biomarkers Bovine serum albumin Integrative top-down proteomics 
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