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It was recently demonstrated in mice that knockout of the flavin-containing monooxygenase 5 gene, Fmo5, slows metabolic ageing via pleiotropic effects. We have now used an NMR-based metabonomics approach to study the effects of ageing directly on the metabolic profiles of urine and plasma from male,...
2018-06-20 | MTBLS667 | MetaboLights
Cyclic dipeptides are produced by organisms across all domains of life, with many exhibiting anticancer and antimicrobial properties. Oxidations are often key to their biological activities, particularly C-C bond oxidation catalyzed by tailoring enzymes including cyclodipeptide oxidases. These flavi...
ORGANISM(S): Nocardiopsis dassonvillei 
2025-01-06 | PXD058613 | Pride
Sterols are ubiquitous membrane constituents that persist to a large extent in the environment due to their water insolubility and chemical inertness. Recently, an oxygenase-independent sterol degradation pathway was discovered in a cholesterol-grown denitrifying bacterium Sterolibacterium (S.) deni...
ORGANISM(S): Sterolibacterium denitrificans 
2024-05-21 | PXD048763 | Pride
Genomics
novel flavin-adsorbing polyurethane foam
The growing appreciation of immune cell-cell interactions within disease environments has led to significant efforts to develop highly effective protein- and cell-based immunotherapies. However, characterizing these complex cell-cell interfaces in high resolution remains challenging. Thus, technol...
ORGANISM(S): Bos taurus (Bovine) Oryctolagus cuniculus (Rabbit) Gallus gallus (Chicken) 
2022-06-03 | PXD032203 | Pride
Hepatitis C virus RNA is 5’ flavin adenine dinucleotide (FAD) capped
Adipogenic differentiation and metabolic adaptation are initiated through transcriptional and epigenetic reprogramming. In particular, dynamic changes in histone modifications may play central roles in the rearrangement of gene expression patterns. LSD1 (KDM1) protein, encoded by aof2 gene, is a his...
ORGANISM(S): Mus musculus 
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