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TranscriptomicsPhevalin (aureusimine B) production by Staphylococcus aureus biofilm and impacts on human keratinocyte gene expression
Staphylococcus aureus produces the cyclic dipeptides tyrvalin and phevalin (aureusimine A and B, respectively). A previous study reported that S. aureus mutants not capable of producing these compounds were less virulent in vivo through the deranged regulation of virulence factor genes. These findin...
ORGANISM(S): Homo sapiens 
2012-10-01 | E-GEOD-32920 | biostudies-arrayexpress
TranscriptomicsMicrosensor and transcriptome signatures of oxygen depletion in biofilms associated with chronic wounds [biofilm inoculum]
Biofilms have been implicated in delayed wound healing, although the mechanisms by which biofilms impair wound healing are poorly understood. Many species of bacteria produce exotoxins and exoenzymes that may inhibit healing. In addition, oxygen consumption by biofilms, as well as responding leukocy...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2015-11-24 | E-GEOD-75359 | biostudies-arrayexpress
TranscriptomicsSecreted Factors from Staphylococcus aureus Biofilm and Planktonic Cultures Differentially Impact Human Keratinocytes, in vitro
Interactions between human keratinocytes and secreted factors from Staphylococcus aureus biofilm and planktonic cultures were investigated using microarray analysis. Relative to planktonic secreted factors, biofilm secreted factors up regulated cytokine and chemokine genes in keratinocytes. Genes ...
ORGANISM(S): Homo sapiens 
2011-08-30 | E-GEOD-24118 | biostudies-arrayexpress
TranscriptomicsSecreted Factors from Staphylococcus aureus Biofilm and Planktonic Cultures Differentially Impact Human Keratinocytes in vitro
Interactions between human keratinocytes and secreted factors from Staphylococcus aureus biofilm were investigated using microarray analysis. Relative to control cells, biofilm-secreted factors upregulated cytokine and chemokine genes in keratinocytes. Genes associated with DNA damage and oxidative ...
ORGANISM(S): Homo sapiens 
2011-08-30 | E-GEOD-24370 | biostudies-arrayexpress
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