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TranscriptomicsImatinib targeting of KIT-mutant oncoprotein in melanoma
Metastatic melanoma is an aggressive treatment-refractory malignancy. Recently, c-Kit mutations were discovered in certain mucosal melanomas. A clinical trial was initiated with the c-Kit inhibitor imatinib mesylate. The first treated patient experienced dramatic clinical improvement within days, f...
ORGANISM(S): Homo sapiens 
2008-12-23 | E-GEOD-8164 | biostudies-arrayexpress
UnknownEfficacy and safety of regorafenib in patients with metastatic and/or unresectable GI stromal tumor after failure of imatinib and sunitinib: a multicenter phase II trial.
Not available
S-EPMC3675695 | biostudies-literature
UnknownImatinib for melanomas harboring mutationally activated or amplified KIT arising on mucosal, acral, and chronically sun-damaged skin.
Not available
S-EPMC4878082 | biostudies-literature
ProteomicsThe Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation: siEYA4 pY IP-MS
The Eyes Absent family of proteins (EYA1-4) are a biochemically unique group of tyrosine phosphatases known to be tumour promoting across a range of cancer types. To date, the molecular targets of EYA phosphatase activity remain largely uncharacterised. Here, we identify Polo-like kinase 1 (PLK1) as...
ORGANISM(S): Homo sapiens (Human) 
2024-02-26 | PXD036430 | Pride
Py ip Eya4 
ProteomicsThe Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation: EYA4 BioID
The aim of this project was to identify the EYA4 interactome. This was part of a larger research goal of identifying EYA4 phosphatase substrates and the cell biological consequences of their dephosphorylation.
ORGANISM(S): Homo sapiens (Human) 
2024-02-26 | PXD036405 | Pride
Eya4 Bioid 
UnknownMitochondrial activity promotes neutrophil degranulation and endothelial dysfunction in systemic infections
Not available
S-SCDT-10_1038-S44321-026-00453-1 | biostudies-other
Transcriptomicslow and high aerobic capacity rats exposed to cigarette smoke, lung tissue
Low aerobic exercise capacity increases susceptibility to smoking-induced inflammation and tissue damage 38 animals total: 12 HCR Smoke, 12 LCR Smoke, 7 HCR sham, 7 LCR sham
ORGANISM(S): Rattus norvegicus 
2016-02-15 | E-GEOD-22456 | biostudies-arrayexpress
TranscriptomicsGIST cell cycle dysregulation is required for progression to high-risk disease but not for resistance to kinase inhibitors
Background: To understand the transcriptional consequences of a TP53 modulation in the GIST cell context, we treated GIST430 with increasing doses of the MDM2-inhibitor nutlin-3 (racemate). In this study, 3’ end RNA Sequencing (3SEQ) was used to expression profile GIST430 cell lines treated with DMS...
ORGANISM(S): Homo sapiens 
2014-12-25 | E-GEOD-59841 | biostudies-arrayexpress
UnknownPrognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study.
Not available
S-EPMC6254006 | biostudies-literature
UnknownRelationship Between Severity of Ischemia and Coronary Artery Disease for Different Stress Test Modalities in the ISCHEMIA Trial.
Not available
S-EPMC11658795 | biostudies-literature
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