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ProteomicsThe Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation: EYA4 BioID
The aim of this project was to identify the EYA4 interactome. This was part of a larger research goal of identifying EYA4 phosphatase substrates and the cell biological consequences of their dephosphorylation.
ORGANISM(S): Homo sapiens (Human) 
2024-02-26 | PXD036405 | Pride
Eya4 Bioid 
ProteomicsThe Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation: PLK1 PRM
The aim of these experiments was to quantify PLK1 tyrosine phosphosites with respect to EYA4 and EYA1. PRM was performed on immunopurified PLK1. This was part of a larger project to characterize the effects of EYA4 mediated dephosphorylation on PLK1 functions.
ORGANISM(S): Homo sapiens (Human) 
2024-02-26 | PXD037064 | Pride
Plk1 prm 
ProteomicsThe Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation: siEYA4 pY IP-MS
The Eyes Absent family of proteins (EYA1-4) are a biochemically unique group of tyrosine phosphatases known to be tumour promoting across a range of cancer types. To date, the molecular targets of EYA phosphatase activity remain largely uncharacterised. Here, we identify Polo-like kinase 1 (PLK1) as...
ORGANISM(S): Homo sapiens (Human) 
2024-02-26 | PXD036430 | Pride
Py ip Eya4 
Methylation profilingEYA4 is a non-small cell lung cancer tumor suppressor located in the susceptibility locus on chromosome 6q
This study was undertaken to identify novel tumour suppressor genes in lung adenocarcinoma. EYA4, located at 6q23.2 was identified as a frequently lost and hypermethylated gene in the analyzed samples. EYA4 is underexpressed in addition to being deleted and hypermethylated. Control of EYA4 expressio...
ORGANISM(S): Homo sapiens 
2014-02-25 | GSE19034 | GEO
UnknownEya4-deficient mice are a model for heritable otitis media.
Not available
S-EPMC2213371 | biostudies-literature
UnknownEYA4 inhibits hepatocellular carcinoma by repressing MYCBP by dephosphorylating β-catenin at Ser552.
Not available
S-EPMC6778622 | biostudies-literature
UnknownTripartite motif containing 69 elicits ERK2-dependent EYA4 turnover to impart pancreatic tumorigenesis.
Not available
S-EPMC9891873 | biostudies-literature
Genomics
Novel mutations on the EMD and EYA4
PRJNA953961 | ENA
UnknownPrevalence and clinical features of hearing loss caused by EYA4 variants.
Not available
S-EPMC7046659 | biostudies-literature
UnknownEYA4 promotes breast cancer progression and metastasis through its role in replication stress avoidance.
Not available
S-EPMC10543271 | biostudies-literature
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