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MetabolomicsLACTIN-V (Lactobacillus crispatus CTV-05) leads to microbial and immune modulation in pregnant women at risk of spontaneous preterm birth: FLIP-1 study

Preterm birth (PTB) remains a leading cause of neonatal morbidity and mortality, with no new preventive therapeutics introduced since the 1970s. Evidence increasingly implicates adverse vaginal microbiome-immune interactions in its aetiology. We report the effects of the live biotherapeutic, Lact...

2026-10-02 | MTBLS15899 | MetaboLights
GenomicsFatal cytokine release syndrome by an aberrant FLIP/STAT3 axis
Fatal cytokine release syndrome by an aberrant FLIP/STAT3 axis
PRJNA706022 | ENA
ProteomicsFliP subcomplex analysis - A flagellum-specific chaperone facilitates assembly of the core type III export apparatus of the bacterial flagellum
Biosynthesis of the bacterial flagellum depends on a flagellar-specific type III secretion system (T3SS), a protein export machine homologous to the export machinery of the virulence-associated injectisome. Six cytoplasmic (FliH/I/J/G/M/N) and seven integral membrane proteins (FlhA/B FliF/O/P/Q/R) f...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium 
2017-08-22 | PXD005597 | Pride
Export gate complex Flio T3ss Flip Assembly 
TranscriptomicsRNA-seq in fetal mice brain following c-Flip knockdown
We characterized the comprehensive set of differentially expressed genes resulting from the knockdown of c-Flip in the E13.5 fetal head and identified the transcriptional profile of ZIKV-induced DEGs in the context of c-Flip deficiency
ORGANISM(S): Mus musculus 
2024-11-10 | GSE254990 | GEO
TranscriptomicsTranscriptome profiling during cutaneous porcine wound repair.
The expression profile during wound repair of cutaneous excisional wound (2x2 cm) was studied. The tissue was sampled from the centre of the open wound (day 3/7/14) or centre of the wound scar (day 21/35/70). The microarray slide were scanned in low intensity scan and high intensity scan mode. Wound...
ORGANISM(S): Sus scrofa 
2012-07-29 | E-GEOD-37947 | biostudies-arrayexpress
TranscriptomicsFLIP modulates monocyte immunosuppression and selective resistance to chemotherapy
To investigate the genes differentially induced by c-FLIP up-regulation by lentivirus infection in monocytes from healthy donors
ORGANISM(S): Homo sapiens 
2018-12-01 | GSE101587 | GEO
TranscriptomicsFatal cytokine release syndrome by an aberrant FLIP/STAT3 axis
Inflammatory responses rapidly detect pathogen invasion and mount a regulated reaction. However, dysregulated anti-pathogen immune responses can provoke life-threatening inflammatory pathologies collectively known as cytokine release syndrome (CRS), exemplified by key clinical phenotypes unearthed d...
ORGANISM(S): Mus musculus 
2021-09-09 | GSE168098 | GEO
Genomics
Flavobacterium FLiP bacteriophage hosts
PRJNA947224 | ENA
UnknownThe c-FLIP-NH2 terminus (p22-FLIP) induces NF-kappaB activation.
Not available
S-EPMC2121210 | biostudies-literature
ProteomicsEvidence for a ‘trap-and-flip’ mechanism in a proton-dependent lipid transporter
Lipid transporters from the major facilitator superfamily (MFS) have been reported to play central roles in diverse fundamental biological pathways. However, little is known about their transport mechanisms and only the structure of the MFS lipid transporter LtaA in an outward-facing conformation ha...
ORGANISM(S): Staphylococcus aureus subsp. aureus NCTC 8325 
2022-05-16 | PXD031166 | Pride
Ltaa Targeted mass spectrometry 
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