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TranscriptomicsTunable protein synthesis by transcript isoforms in human cells (Transcript Isoforms in Polysomes sequencing: TrIP-seq)
Eukaryotic genes generate multiple mRNA transcript isoforms though alternative transcription, splicing, and polyadenylation. However, the relationship between human transcript diversity and protein production is complex as each isoform can be translated differently. We fractionated a polysome profil...
ORGANISM(S): Homo sapiens 
2016-01-11 | E-GEOD-69352 | biostudies-arrayexpress
TranscriptomicsRocaglamide A converts RNA helicase eIF4A into a sequence-specific translational repressor
Rocaglamide A (RocA) typifies a novel class of protein synthesis inhibitors that selectively kill aneuploid tumor cells and repress translation of specific mRNAs. RocA targets eukaryotic initiation factor 4A (eIF4A), the prototypical DEAD-box RNA helicase, and its mRNA selectivity is proposed to ref...
ORGANISM(S): synthetic construct 
2016-06-15 | E-GEOD-70211 | biostudies-arrayexpress
TranscriptomicsRocaglates convert DEAD-box protein eIF4A into a sequence-selective translational repressor
Rocaglamide A (RocA) typifies a class of protein synthesis inhibitors that selectively kill aneuploid tumor cells and repress translation of specific mRNAs. RocA targets eukaryotic initiation factor 4A (eIF4A), an ATP-dependent DEAD-box RNA helicase; its mRNA selectivity is proposed to reflect highl...
ORGANISM(S): synthetic construct 
2016-06-15 | E-GEOD-79392 | biostudies-arrayexpress
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