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TranscriptomicsTunable protein synthesis by transcript isoforms in human cells (Transcript Isoforms in Polysomes sequencing: TrIP-seq)
Eukaryotic genes generate multiple mRNA transcript isoforms though alternative transcription, splicing, and polyadenylation. However, the relationship between human transcript diversity and protein production is complex as each isoform can be translated differently. We fractionated a polysome profil...
ORGANISM(S): Homo sapiens 
2016-01-11 | E-GEOD-69352 | biostudies-arrayexpress
TranscriptomicsRocaglamide A converts RNA helicase eIF4A into a sequence-specific translational repressor
Rocaglamide A (RocA) typifies a novel class of protein synthesis inhibitors that selectively kill aneuploid tumor cells and repress translation of specific mRNAs. RocA targets eukaryotic initiation factor 4A (eIF4A), the prototypical DEAD-box RNA helicase, and its mRNA selectivity is proposed to ref...
ORGANISM(S): synthetic construct 
2016-06-15 | E-GEOD-70211 | biostudies-arrayexpress
TranscriptomicsRocaglates convert DEAD-box protein eIF4A into a sequence-selective translational repressor
Rocaglamide A (RocA) typifies a class of protein synthesis inhibitors that selectively kill aneuploid tumor cells and repress translation of specific mRNAs. RocA targets eukaryotic initiation factor 4A (eIF4A), an ATP-dependent DEAD-box RNA helicase; its mRNA selectivity is proposed to reflect highl...
ORGANISM(S): synthetic construct 
2016-06-15 | E-GEOD-79392 | biostudies-arrayexpress
TranscriptomicsS. aureus gene expression during growth phase and/or S. aureusâ??PMN interaction
To measure S. aureus gene expression during growth phase and/or S. aureusâ??PMN interaction.
ORGANISM(S): Staphylococcus aureus 
2010-06-09 | E-GEOD-2728 | biostudies-arrayexpress
UnknownIGHMBP2 deletion suppresses translation and activates the integrated stress response.
Not available
S-EPMC11109757 | biostudies-literature
UnknownRNA molecular recording with an engineered RNA deaminase.
Not available
S-EPMC11497829 | biostudies-literature
UnknownGli3 coordinates three-dimensional patterning and growth of the tectum and cerebellum by integrating Shh and Fgf8 signaling.
Not available
S-EPMC2673693 | biostudies-literature
UnknownTemporal control of axonal floor plate crossing through a combination of incoherent feedforward and feedback loops of gene regulatory network regulating Robo3 expression.
Not available
S-EPMC12636605 | biostudies-literature
UnknownBurden of cancers in India - estimates of cancer crude incidence, YLLs, YLDs and DALYs for 2021 and 2025 based on National Cancer Registry Program.
Not available
S-EPMC9092762 | biostudies-literature
TranscriptomicsHigh-throughput gene expression profiling of Salmonella enterica serovar Paratyphi A in the blood of bacteremic patients in Bangladesh
In this work, we applied an RNA analysis method, Selective Capture of Transcribed Sequences (SCOTS), and cDNA hybridization-microarray technology to identify S. Paratyphi A transcripts expressed by bacteria in the blood of three patients in Bangladesh. In total, we detected 1798 S. Paratyphi A mRNA...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Paratyphi A 
2010-09-06 | E-GEOD-22958 | biostudies-arrayexpress
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