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GenomicsNational Institute on Aging (NIA) Long Life Family Study (LLFS)

The Long Life Family Study (LLFS) is an international collaborative study of the genetics and familial components of exceptional survival, longevity, and healthy aging. Families were recruited through elderly probands (generally in their 90s) who self-reported on the survival history of their par...

phs000397.v1.p1 | EGA
TranscriptomicsExpression analyses of E12.5 embryonic brains from Nestin Cre+, Rest GTi/GTi, p53 fl/fl vs Rest GTi/GTi, p53 fl/fl littermates
We use mice containing a gene trap in the first intron of the Rest gene, which effectively eliminates transcription from all coding exons, to prematurely remove REST from neural progenitors. We find catastrophic DNA damage that occurs during S-phase of the cell cycle, with consequences including ab...
ORGANISM(S): Mus musculus 
2015-08-01 | E-GEOD-68368 | biostudies-arrayexpress
TranscriptomicsMusashi 2 is a regulator of the hematopoietic stem cell compartment identified by a retroviral insertion screen and knockout mice
We have used a retroviral integration screen to search for novel genes that regulate hematopoietic stem cell (HSC) function. One of the genes that conferred HSC dominance when overexpressed due to an adjacent retroviral insertion was Musashi 2 (Msi2), an RNA binding protein that can act as a transla...
ORGANISM(S): Mus musculus 
2011-05-21 | E-GEOD-29432 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse HDAC2 knockout myocardium
We used microarrays to detail the global programme of gene expression underlying cardiac development by HDAC2 and identified distinct classes of up-regulated and down-regulated genes during this process. Experiment Overall Design: Embryonic heart ventricles were dissected at E17.5 for RNA extraction...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-6770 | biostudies-arrayexpress
TranscriptomicsExpression analyses of E12.5 embryonic brains from Nestin Cre+, Rest GTi/GTi vs Rest GTi/GTi litermates
We use mice containing a gene trap in the first intron of the Rest gene, which effectively eliminates transcription from all coding exons, to prematurely remove REST from neural progenitors. We find catastrophic DNA damage that occurs during S-phase of the cell cycle and concominant with activation...
ORGANISM(S): Mus musculus 
2015-08-01 | E-GEOD-68459 | biostudies-arrayexpress
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