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MetabolomicsMetabolome and transcriptome combined profiling reveals fluconazole resistance mechanisms of Trichosporon asahii and role of farnesol in fluconazole tolerance

Trichosporon asahii is a basidiomycete yeast that is pathogenic to humans and animals, and fluconazole-resistant strains have recently increased. Farnesol secreted by fungi is a factor that causes variations in fluconazole resistance; however, few studies have explored the underlying mec...

2023-11-20 | MTBLS7236 | MetaboLights
TranscriptomicsGene expression in response to fluconazole vs. the combination of fluconazole and berberine
Transcriptional profiling of Candida albicans comparing fluconazole treated cells with fluconazole- and berberine-treated cells, as well untreated cells with berberine treated cells Three different clinical FLC-resistant strains (0304103, 01010 and 632) were selected to carry out the expression prof...
ORGANISM(S): Candida albicans 
2013-11-14 | E-GEOD-43662 | biostudies-arrayexpress
TranscriptomicsEvolutionary divergence in the fungal response to fluconazole revealed by soft clustering (S. cerevisiae, C. glabrata, K. lactis)
Fungal infections are an emerging health risk, especially those involving yeast that are resistant to antifungal agents. To understand the range of mechanisms by which yeasts can respond to anti-fungals, we compared gene expression patterns across three evolutionarily distant species - Saccharomyces...
ORGANISM(S): Candida glabrata 
2010-07-08 | E-GEOD-15710 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization by array of east haploid and heterozygous essential deletion pools treated with compounds synergistic with fluconazole to identify sensitive and resistant mutants
The haploid and the heterozygous essential S.cerevisiae deletion pools were grown in the presence of compounds that we found to be synergistic with fluconazole. We also treated the deletion pools with combinations of those drugs and fluconazole to interrogate the mechanism of action of the drug inte...
ORGANISM(S): Saccharomyces cerevisiae 
2011-09-07 | E-MTAB-394 | biostudies-arrayexpress
TranscriptomicsMutation in Transcription Factor Upc2p Causes Upregulation of Ergosterol Biosynthesis Genes and Fluconazole Resistance
In the pathogenic yeast Candida albicans, the zinc cluster transcription factor Upc2p has been shown to regulate expression of ERG11 and other genes involved in ergosterol biosynthesis upon exposure to azole antifungals. ERG11 encodes lanosterol demethylase, the target enzyme of this antifungal cla...
ORGANISM(S): Candida albicans 
2008-11-04 | E-GEOD-11320 | biostudies-arrayexpress
ProteomicsC.albicans LC-MSMS lysine lactylated
C.albicans strain Ca1, retrieved from an AIDS patient, was obtained from T. C. White (School of Biological Sciences, University of Missouri at Kansas City, Kansas City, MO, USA), and was grown on yeast extract-peptone-dextrose (YPD) agar medium. For the selection of Ca1-T cells, YPD medium containin...
ORGANISM(S): Candida albicans 23R 
2025-09-25 | PXD056982 | Pride
Lysine lactylated Lc-msms 
GenomicsMistranslation accelerates the adaptation of Candida albicans to Fluconazole
The leucine CUG codon was reassigned to serine in the fungal pathogen Candida albicans. To clarify the biological role of this tuneable codon ambiguity on drug resistance, we evolved C. albicans strains that were engineered to mistranslate the CUG codon at constitutively elevated levels, in the pres...
ORGANISM(S): Candida albicans 
2016-10-27 | E-SYBR-13 | biostudies-arrayexpress
no omics definedTranscription profiling of Candida albicans biofilm exposed to amphotericin B, fluconazole or two concentrations of caspofungin
30h of growth biofilms in microfermentors were exposed to caspofungin 0.5 µg/ml, caspofungin 5 µg/ml, fluconazole 80 µg/ml or amphotericin B 8 µg/ml. Control and antifungal-exposed biofilms were recovered at t= 0, 30, 60 and 120 min post exposure to antifungal.
ORGANISM(S): Candida albicans 
2010-03-02 | E-MEXP-2436 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of Cryptococcus gattii treated with fluconazole
Log phase cells of C. gattii strain Cga681 was treated with fluconazole for 3 hours. Transcriptome was compared to no treatment control.
ORGANISM(S): Cryptococcus gattii 
2026-09-18 | E-MTAB-16897 | biostudies-arrayexpress
TranscriptomicsA defect in iron uptake enhances the susceptibility of Cryptococcus neoformans to azole antifungal drugs.
Transcriptome profiling of wild type and cfo1 mutant with fluconazole treatment in Cryptococcus neoformans var. grubii H99 Purpose: The goals of this study are to compare cfo1 mutant transcriptome profiling (RNA-seq) to wild-type with or without fluconazole treatment in Cryptococcus neoformans var. ...
ORGANISM(S): Cryptococcus neoformans var. grubii H99 
2013-05-31 | E-GEOD-37875 | biostudies-arrayexpress
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