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MetabolomicsIntegrated transcriptome and metabolome analysis reveals the regulatory mechanism underlying fluoride tolerance in XSKD silkworm strain
XueSong KD (XSKD) is a fluoride-tolerant Bombyx mori strain that grows normally under long-term fluoride exposure, whereas its molecular tolerance mechanism remains elusive. Herein, we performed combined transcriptomic and untargeted metabolomic profiling using pre-molt fourth-instar XSKD larvae fed...
2026-07-07 | MTBLS14966 | MetaboLights
TranscriptomicsGene expression profiling of HOS (human osteosarcoma) cells exposed to fluoride
Though fluoride is considered an essential trace element, chronic exposure to fluoride is known to cause toxic effects. Chronic exposure of high concentration of fluoride may leads to fluorosis. To understand the molecular mechanism of fluoride induced toxicity gene expression profiling was performe...
ORGANISM(S): Homo sapiens 
2016-06-30 | E-GEOD-70719 | biostudies-arrayexpress
TranscriptomicsMicromolar fluoride alters ameloblast lineage cells in vitro
Previously characterized ameloblast-lineage cells were used in this study to determine whether micromolar levels of fluoride could be directly affect these cells. Six samples altogether were analyzed in this study. Every two of them were from a same biological souce and subject to with or without th...
ORGANISM(S): Homo sapiens 
2010-06-30 | E-GEOD-5365 | biostudies-arrayexpress
MetabolomicsThe Metabolomics of Oral Biofilms exposed to Arginine and Fluoride
Not available
ORGANISM(S): Homo sapiens 
ST000583 | MetabolomicsWorkbench
TranscriptomicsThe differentially expressed genes of A. ferrooxidans ATCC 23270 at different time after introduced fluoride
The deleterious fluoride ions, which released from fluoride in uranium during its bioleaching, strongly influenced microbial growth, energy intake, enzyme activity and relative metabolism. Whole-genome microarrays were used to obtain a comprehensive description of the molecular response by A. ferroo...
ORGANISM(S): Acidithiobacillus ferrooxidans ATCC 23270 
2016-07-03 | E-GEOD-76450 | biostudies-arrayexpress
TranscriptomicsmiRNA expression profile in HOS cells exposed to sodium fluoride
Fluorosis is caused due to excess of fluoride intake over a long period of time. Aberrant change in RUNX2-mediated signaling cascade is one of the decisive steps during the pathogenesis of fluorosis. Till date, role of fluoride on the epigenetic alterations is not studied. In the present study, glob...
ORGANISM(S): Homo sapiens 
2015-01-01 | E-GEOD-57550 | biostudies-arrayexpress
GenomicsFluoride effects
EFFECTS OF SODIUM FLUORIDE OVER ORAL BACTERIAL BIOFILMS COMPOSITION AND ACTIVITY
PRJEB35662 | ENA
ProteomicsMechanisms affecting fluoride tolerance in the environmental bacterium Pseudomonas putida
Fluoride is the anionic form of fluorine, the 13th most abundant element in Earth's crust, and it is toxic to many organisms above a threshold concentration. Environmental bacteria can withstand relatively high fluoride concentrations, but the only mechanism described so far is the CrcB-dependent ef...
ORGANISM(S): Pseudomonas putida KT2440 
2026-03-30 | PXD068884 | Pride
Pseudomonas putida Compensatory tolerance mechanisms Crcb transporter Benzoate transporter bene-i Fluoride tolerance mechanisms 
ProteomicsA molecular insight into fluoride toxicity in skeletal muscle using invitro C2C12 and in vivo C57BL/6 mice models
Fluoride toxicity in multiple organs has been extensively reported in several decades of research. In-depth study coverage is available on teeth and bone tissues. But studies addressing skeletal muscle fluorosis are scanty. C57BL/6 mice were provided with sodium fluoride in drinking water for 60 day...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD035014 | Pride
Mus musculus Skeletal muscle Sodium fluoride Orbitrap Lc-ms/ms 
TranscriptomicsPlacental methylation profile in women exposed to fluoride and its association with kidney volume at birth
This experiment investigates the relationship between maternal fluoride exposure during pregnancy and DNA methylation patterns in the placenta, aiming to identify epigenetic alterations associated with reduced kidney volume at birth. Placental samples were collected from term deliveries and classifi...
ORGANISM(S): Homo sapiens 
2026-04-07 | E-MTAB-16226 | biostudies-arrayexpress
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