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ProteomicsFast Fluoroalkylation of Proteins Uncovers Structure and Dynamics of Biological Macromolecules
Stable covalent labeling of proteins in combination with mass spectrometry has been established as a complementary technique to classical structural methods, such as X Ray, NMR, or Cryo-EM used for protein structure determination. Although the current stable covalent labeling techniques enable to mo...
ORGANISM(S): Homo sapiens (Human) 
2021-12-30 | PXD027310 | Pride
Radical labeling Mass spectrometry Protein footprinting Conformational changes Fluoroalkylation Hyperva-lent iodine reagents Protein structure Togni reagents Protein fingerprinting Epitope mapping Protein surface mapping Radicals Proteomics Interactomics Trifluoromethylation 
UnknownDiversified Fluoroalkylation of Alkenes Using Quaternary Fluoroalkyl Alcohols as the Fluoroalkylating Reagents.
Not available
S-EPMC11809345 | biostudies-literature
UnknownSynthesis of Hydrofluoroolefin-Based Iodonium Reagent via Dyotropic Rearrangement and Its Utilization in Fluoroalkylation.
Not available
S-EPMC9540448 | biostudies-literature
UnknownFluoroalkylation promotes cytosolic peptide delivery.
Not available
S-EPMC7423368 | biostudies-literature
UnknownUpcycling aromatic polymers through C-H fluoroalkylation.
Not available
S-EPMC6601422 | biostudies-literature
UnknownNucleophilic fluoroalkylation/cyclization route to fluorinated phthalides.
Not available
S-EPMC5789380 | biostudies-literature
UnknownFluoroalkylation of Dextromethorphan Improves CNS Exposure and Metabolic Stability.
Not available
S-EPMC9014517 | biostudies-literature
ProteomicsChemoproteomic Profiling by Cysteine Fluoroalkylation Reveals the DNA Repair Protein XRCC5 as a Functional Target of Myrocin G
Chemoproteomic profiling of cysteines has emerged as a powerful method for screening the proteome-wide targets of cysteine-reactive frag-ments, drugs and natural products. Herein, we report the development and an in-depth evaluation of a tetrafluoroalkyl benziodoxole as a cyste-ine-selective chemopr...
ORGANISM(S): Homo sapiens (Human) 
2021-12-13 | PXD029255 | Pride
Human Q exactive hf-x Natural product Hypervalent iodine Target id Myrocin 
UnknownDecarbonylative Fluoroalkylation at Palladium(II): From Fundamental Organometallic Studies to Catalysis.
Not available
S-EPMC8693446 | biostudies-literature
UnknownEnantiodivergent α-Amino C-H Fluoroalkylation Catalyzed by Engineered Cytochrome P450s.
Not available
S-EPMC6666315 | biostudies-literature
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