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MetabolomicsMetabolic flux analysis of glucose through the glycolytic pathway.

C13 whole-labeled glucose was added into the culture medium of tumor cells to analyze the changes of metabolic flux in glycolytic pathway under metformin treatment or without HK2 knockout, and to analyze the glycolytic link affected by HK2 and metformin treatment.

2025-06-26 | MTBLS12643 | MetaboLights
MetabolomicsGlobal 13C tracing and metabolic flux analysis of intact human liver tissue ex vivo
Liver metabolism is central to human physiology and influences the pathogenesis of common metabolic diseases. Yet, our understanding of human liver metabolism remains incomplete, with much of current knowledge based on animal or cell culture models that do not fully recapitulate human physiology. He...
2024-07-23 | MTBLS10481 | MetaboLights
MetabolomicsGlycolysis/gluconeogenesis specialization in microbes is driven by biochemical constraints of flux sensing
Central carbon metabolism is highly conserved across microbial species, but can catalyze very different pathways depending on the organism and their ecological niche. Here, we study the dynamic reorganization of central metabolism after switches between the two major opposing pathway configurations ...
2022-01-11 | MTBLS3887 | MetaboLights
MetabolomicsInterorganelle lipid flux revealed by enzymatic mass tagging in vivo
The distinct activities of cellular organelles are dependent on the proper function of their membranes. Coordinated membrane biogenesis of the different organelles necessitates interorganelle transport of lipids from their site of synthesis to their destination membranes. Several proteins and traffi...
2022-03-22 | MTBLS3415 | MetaboLights
MetabolomicsSIN-3 transcriptional coregulator maintains mitochondrial homeostasis and polyamine flux
Mitochondrial function relies on the coordinated transcription of mitochondrial and nuclear genomes to assemble respiratory chain complexes. Across species, the SIN3 coregulator influences mitochondrial functions, but how its loss impacts mitochondrial homeostasis and metabolism in the context of a ...
2024-04-01 | MTBLS8439 | MetaboLights
MetabolomicsGlucose flux analysis of NLRP3 inflammasome activated macrophages
Not available
ORGANISM(S): Mus musculus 
ST002379 | MetabolomicsWorkbench
MetabolomicsSystem-level analysis of flux regulation of yeast show that glycolytic flux is controlled by allosteric regulation and enzyme phosphorylation
Not available
ORGANISM(S): Saccharomyces cerevisiae 
ST002397 | MetabolomicsWorkbench
MetabolomicsCharacterization of Phytoplankton-Excreted Metabolites Mediating Carbon Flux through the Surface Ocean

The marine labile dissolved organic carbon (DOC) pool is a dynamic reservoir of thousands of molecules. After excretion or release by phytoplankton and other microbes, metabolites are rapidly consumed, resulting in very low standing concentrations (picomolar to low nanomolar). To date, marine phy...

2026-03-17 | MTBLS12895 | MetaboLights
MetabolomicsMitochondrial respiration in B lymphocytes is essential for humoral immunity by controlling flux of the TCA cycle

To elucidate the function of oxidative phosphorylation (OxPhos) during B-cell differentiation we employ CD23Cre-driven expression of the dominant-negative K320E mutant of the mitochondrial helicase Twinkle (DNT). DNT-expression depletes mitochondrial DNA during B cell maturation, reduces the abun...

2026-08-21 | MTBLS4647 | MetaboLights
Metabolomics13C mass isotopomer analysis (LCMS flux studies) MLL-AF9 (part III)
Not available
ORGANISM(S): Mus musculus 
ST000170 | MetabolomicsWorkbench
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