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MetabolomicsLactiplantibacillus plantarum PS128 restores microbiota-driven polyamine homeostasis to alleviate autism-like behaviors in Fmr1 knockout mice

Background: Autism spectrum disorder (ASD) is biologically heterogeneous and has limited mechanism-informed interventions targeting core behavioral symptoms. Emerging evidence suggests that gut microbial metabolism shapes neurobehavioral outcomes, yet the specific metabolic pathw...

2026-02-10 | MTBLS13881 | MetaboLights
MetabolomicsLactiplantibacillus plantarum PS128 restores microbiota-driven polyamine homeostasis to alleviate autism-like behaviors in Fmr1 knockout mice

Background Autism spectrum disorder (ASD) is biologically heterogeneous and has limited mechanism-informed interventions targeting core behavioral symptoms. Emerging evidence suggests that gut microbial metabolism shapes neurobehavioral outcomes, yet the specific metabolic pathwa...

2026-02-06 | MTBLS13859 | MetaboLights
MetabolomicsLactiplantibacillus plantarum PS128 restores microbiota-driven polyamine homeostasis to alleviate autism-like behaviors in Fmr1 knockout mice

Background: Autism spectrum disorder (ASD) is biologically heterogeneous and has limited mechanism-informed interventions targeting core behavioral symptoms. Emerging evidence suggests that gut microbial metabolism shapes neurobehavioral outcomes, yet the...

2026-02-07 | MTBLS13862 | MetaboLights
ProteomicsMass spectrometry analysis of synaptic proteome of adult Fmr1 KO and wild-type mice.
Fragile X syndrome (FXS) is the most common monogenetic cause of inherited intellectual disability and autism in humans. One of the well-characterized molecular phenotypes of Fmr1 KO mice, a model of FXS, is increased translation of synaptic proteins. Although this upregulation stabilizes in the adu...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD043700 | Pride
Brain Synaptoneurosomes Fmr1 ko mice 
TranscriptomicsGene Expression Analysis of Fmr1-KO Mouse Caudate Putamen as a Model of Fragile X-Syndrome Compared to Wild-Type Mouse
A gene sequencing analysis of caudate putamen tissue of Fmr1-KO mice in comparison to wild-type mice was performed to identify new pre-clinical tissue biomarkers that might be relevant in Fragile X-Syndrome.
ORGANISM(S): Mus musculus 
2026-09-25 | E-MTAB-17716 | biostudies-arrayexpress
TranscriptomicsComparison of total and polyribosome-associated mRNA levels in male Fmr1 KO mice and male WT littermates
The Fragile X Mental Retardation Protein, FMRP, is thought to regulate the translation of a specific set of neuronal mRNAs on polyribosomes. Therefore, we prepared polyribosomes on sucrose gradients and purified mRNA specifically from these fractions, as well as the total mRNA levels, to determine ...
ORGANISM(S): Mus musculus 
2011-07-20 | E-GEOD-26745 | biostudies-arrayexpress
UnknownAltered olfactory responses in Fmr1 KO mice.
Not available
S-EPMC11758012 | biostudies-literature
UnknownDecreased home cage movement and oromotor impairments in adult Fmr1-KO mice.
Not available
S-EPMC6042514 | biostudies-literature
UnknownComprehensive motor testing in Fmr1-KO mice exposes temporal defects in oromotor coordination.
Not available
S-EPMC4874324 | biostudies-literature
UnknownRescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486.
Not available
S-EPMC3619302 | biostudies-literature
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