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Hippocampal synaptoneurosomes from WT and Ts1Cje mice were analyzed by 4-plex iTRAQ. Technical replicates were included.
ORGANISM(S): Mus musculus (Mouse) 
2022-03-01 | PXD008576 | Pride
In Alzheimer's disease (AD), early deficits in learning and memory are a consequence of synaptic modification which are likely induced by toxic beta-amyloid oligomers (dAbeta). To identify molecular targets downstream of dAbeta binding we prepared synaptoneurosomes from frontal cortex of control a...
ORGANISM(S): Homo sapiens 
Hippocampal synaptoneurosomes from WT and Ts1Cje mice treated or not with rapamycin were analyzed by 8-plex iTRAQ. Technical replicates were included.
ORGANISM(S): Mus musculus (Mouse) 
2018-07-04 | PXD008569 | Pride
Temporal and target-specific S-palmitoylation of synaptic proteins supports synapse and neural network plasticity: Synaptic plasticity is a phenomenon essential for learning and memory, which relies on activity-dependent changes in neural connectivity. S-palmitoylation, a reversible posttranslation...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-10-20 | PXD058417 | Pride
Fragile X syndrome (FXS) is the most common monogenetic cause of inherited intellectual disability and autism in humans. One of the well-characterized molecular phenotypes of Fmr1 KO mice, a model of FXS, is increased translation of synaptic proteins. Although this upregulation stabilizes in the adu...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD043700 | Pride
RNA-seq of cortical synaptoneurosomes from MNK1 and MNK2 KO mice.
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