Focal adhesion kinase (fak)

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Lab affiliation

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA (2)
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u o edinburgh (1)
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Department of Pediatrics Indiana University School of Medicine Riley Hospital for Children (1)
Centre for Haemato-oncology, Barts Cancer Institute, Queen Mary University of London, London, EC1M6BQ, UK (1)
Centre for Genomics and Computational Biology Barts Cancer Institute Queen Mary, University of London John Vane Science Centre, Charterhouse Square, London EC1M 6BQ Tel: +44 (0)20 7882 8266 | Fax: +44 (0)20 7882 3891 | Email: p.cutillas@qmul.ac.uk (1)
Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom (1)
Faculty of Life Sciences, Wellcome Trust Centre for Cell-Matrix Research, University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, United Kingdom (1)
iBET – Instituto de Biologia Experimental e Tecnológica, Av. da República, Oeiras, 2780-157, Portugal (1)
McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 USA (1)
Korea Institute of Science and Technology (1)
King Abdullah University of Science and Technology (1)
Institute of Bioinformatics, Bangalore, Karnataka, India (1)
Reader in Centre for Genomics and Computational Biology Barts Cancer Institute Queen Mary, University of London John Vane Science Centre, Charterhouse Square, London EC1M 6BQ Tel: +44 (0)20 7882 8266 | Fax: +44 (0)20 7882 3891 | Email: p.cutillas@qmul.ac.uk www.bci.qmul.ac.uk/research/centre-profiles/haemato-oncology.html https://www.bci.qmul.ac.uk/en/staff/item/pedro-cutillas (1)
Amsterdam UMC, Vrije Universiteit Amsterdam, Medical Oncology, Cancer Center Amsterdam, OncoProteomics Laboratory, Amsterdam, Netherlands (1)

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siRNA profiling if human MCF-7 cell line to investigate the role of FAK, dominant-negative FAK, FAK-CD and FAKsiRNA in MCF-7 human breast cancer cell tumorigenesis

Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that plays an important role in proliferation, motility, adhesion, invasion, angiogenesis, and survival signaling. Focal adhesion kinase has been shown to be overexpressed in many types of tumors, including breast cancer at early stages o...

ORGANISM(S): Homo sapiens

2009-08-22 | E-GEOD-11581 | biostudies-arrayexpress

Proteomic analysis of integrin-associated adhesion complexes isolated from cells treated with DMSO or FAK inhibitor

Human foreskin fibroblast cells were spread on fibronectin (FN) for 1 h and treated with DMSO or FAK inhibitor (3 uM, AZ13256675 (termed AZ675 for short)) for 1 h. Integrin-associated adhesion complexes isolated from these cells were analysed by mass spectrometry to determine changes in adhesion com...

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

2016-08-23 | MSV000080089 | MassIVE

Expression data from FAK null mouse embryonic fibroblasts treated with endothelin-1

Endothelin-1 (ET-1) plays a critical role in connective tissue remodeling by fibroblasts during tissue repair and fibrosis. We investigated the molecular pathways in the transmission of ET-1 signals that lead to features of connective tissue remodeling, in particular the role of FAK (focal adhesion ...

ORGANISM(S): Mus musculus

2012-06-30 | E-GEOD-30356 | biostudies-arrayexpress

Transcriptome analysis of rat soleus muscle after altered loading state and somatic overexpression of FAK

This SuperSeries is composed of the following subset Series: GSE12743: pCMV-FAK vs pCMV in CTL GSE12744: pCMV-FRNK/pCMV-FAK vs pCMV-FAK in CTL GSE12745: pCMV-FAK vs pCMV in HU GSE12746: pCMV-FAK vs pCMV in R1 GSE12747: pCMV-FAK vs pCMV in R5 Refer to individual Series

ORGANISM(S): Rattus norvegicus

2009-12-30 | E-GEOD-16466 | biostudies-arrayexpress

Xiao-Chai-Hu-Tang alleviates irinotecan-induced diarrhea via TGR5-FAK-RhoA/Rock signaling revealed by integrated metabolomics and proteomics

Irinotecan (CPT-11) is widely used for colorectal cancer treatment, with delayed-onset diarrhea as its primary side effect. Xiao-Chai-Hu-Tang (XCHT) has been clinically observed to alleviate diarrhea, but its mechanisms remain unclear. This study aimed to explore the underlying regulatory mechani...

2025-09-03 | MTBLS12931 | MetaboLights

pCMV-FAK vs pCMV in R1

CMV-driven FAK overexpression in soleus muscle was compared vs empty transfection in contralateral muscle after 1 day of reloading paired comparison in contralateral leg

ORGANISM(S): Rattus norvegicus

2010-06-24 | E-GEOD-12746 | biostudies-arrayexpress

pCMV-FAK vs pCMV in HU

CMV-driven FAK overexpression in soleus muscle was compared vs empty transfection in contralateral muscle after unloading paired comparison in contralateral leg

ORGANISM(S): Rattus norvegicus

2010-06-24 | E-GEOD-12745 | biostudies-arrayexpress

Effect of norepinephrine and focal adhesion kinase (FAK) knockdown in prostate cancer

PRJNA488279 | ENA

Focal Adhesion Kinase Dependent Expression

The goal of this study was to identify transcripts, which are differentially regulatulated in the presence and absence of Focal Adhesion Kinase. As Focal Adhesion Kinase activity can depend upon cell density (Snijder et al. Nature 2009), biological replicates where cells, were seeded very sparsely o...

ORGANISM(S): Mus musculus

2013-09-17 | E-GEOD-43873 | biostudies-arrayexpress

pCMV-FAK vs pCMV in R5

CMV-driven FAK overexpression in soleus muscle was compared vs empty transfection in contralateral muscle after 5 day of reloading paired comparison in contralateral leg

ORGANISM(S): Rattus norvegicus

2009-12-30 | E-GEOD-12747 | biostudies-arrayexpress

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