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TranscriptomicsAnalysis of colorectal tissue from APC- and MYH-associated polyposis patients
Expression profiling is a well established tool for the genome-wide analysis of the transcriptional activity of human neoplasia. However, the high sensitivity of this approach combined with the well-known cellular and molecular heterogeneity of cancer often result in extremely complex and extended e...
ORGANISM(S): Homo sapiens 
2008-04-01 | E-GEOD-9689 | biostudies-arrayexpress
TranscriptomicsBAC CGH array profiling using Phi29-amplified microdissected samples
Details of the experiment are available within the Nucleic Acid Research, 2004 manuscript "Genomic profiling by DNA amplification of laser capture microdissected tissues and array CGH", by Cardoso J. et al.
ORGANISM(S): Homo sapiens 
2010-06-05 | E-GEOD-1841 | biostudies-arrayexpress
TranscriptomicsGene signature of adult mammary stem cells and mammary cancer stem cells (RT_PCR)
The Wnt/beta-catenin signalling pathway plays a central role in mammary stem cell homeostasis and in breast cancer. We employed the CD29hiCD24+ cell surface antigens to identify a subpopulation of mammary CSCs from Apc1572T/+, a mouse model for metaplastic breast adenocarcinoma, a subtype of triple-...
ORGANISM(S): Mus musculus 
2013-08-29 | E-GEOD-40704 | biostudies-arrayexpress
TranscriptomicsGene signature of adult mammary stem cells and mammary cancer stem cells (Affymetrix)
The Wnt/beta-catenin signalling pathway plays a central role in mammary stem cell homeostasis and in breast cancer. We employed the CD29hiCD24+ cell surface antigens to identify a subpopulation of mammary CSCs from Apc1572T/+, a mouse model for metaplastic breast adenocarcinoma, a subtype of triple-...
ORGANISM(S): Mus musculus 
2013-08-29 | E-GEOD-40702 | biostudies-arrayexpress
TranscriptomicsHigh levels of canonical Wnt signaling lead to loss of stemness and increased differentiation in hematopoietic stem cells
Canonical Wnt signalling regulates the self-renewal of most if not all stem cell systems. In the blood system, the role of Wnt signalling has been subject of much debate, with positive and negative roles of Wnt signalling proposed for hematopoietic stem cells (HSC). As we have shown previously, this...
ORGANISM(S): Mus musculus 
2016-03-23 | E-GEOD-79495 | biostudies-arrayexpress
TranscriptomicsExpression data from subpopulations of Apc1638N/+ intestinal adeno tumors versus Apc1638N/+ / KRAS v12G intestinal adenocarcinomas tumors
Constitutive activation of the Wnt pathway leads to adenoma formation, an obligatory step towards intestinal cancer. In view of the established role of Wnt in regulating stemness, we attempted the isolation of cancer stem cells (CSCs) from Apc- and Apc/KRAS-mutant intestinal tumours. Whereas CSCs ar...
ORGANISM(S): Mus musculus 
2013-10-01 | E-GEOD-47772 | biostudies-arrayexpress
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