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TranscriptomicsTowards understanding breast cancer mechanisms to metastasize
How organ-specific metastatic traits accumulate in primary tumors remains unknown. We identified a role of the primary tumor stroma in selecting breast cancer cells that are primed for metastasis in the bone. A fibroblast-rich stroma in breast tumors creates a microenvironment that is similar to tha...
ORGANISM(S): Homo sapiens 
2013-11-01 | E-GEOD-47389 | biostudies-arrayexpress
UnknownImprovement of the clinical applicability of the Genomic Grade Index through a qRT-PCR test performed on frozen and formalin-fixed paraffin-embedded tissues.
Not available
S-EPMC2756282 | biostudies-literature
GenomicsGenome-wide DNA methylation profiles of non-small cell lung carcinomas and control lung tissues
Purpose: Generate genome-wide methylation profiles of non-small cell lung carcinomas (NSCLC) and their matching lung tissues for detection of hypermethylated and hypomethylated regions present in the tumors. Methods: MethylCapture followed by next-generation sequencing (Illumina GAIIx) of 7 nsclc tu...
ORGANISM(S): Homo sapiens 
2012-10-05 | E-GEOD-41343 | biostudies-arrayexpress
TranscriptomicsExpression data from breast cancer cell lines
Breast cancer is a genetically and phenotypically complex disease. To understand the role of microRNAs in this molecular complexity, we performed miRNA expression analysis in a cohort of molecularly well-characterized human breast cancer (BC) cell lines to discover miRNAs associated with the most co...
ORGANISM(S): Homo sapiens 
2013-04-22 | E-GEOD-41313 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human primary breast tumors
Brain metastasis is one of the most feared complications of cancer and the most common intracranial malignancy in adults. Its underlying mechanisms remain unknown. From breast cancer patients with metastatic disease we isolated cell populations that aggressively colonize the brain. Transcriptomic an...
ORGANISM(S): Homo sapiens 
2009-06-23 | E-GEOD-12276 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human breast cancers and lung metastatis
Validation of lung metastasis signature (LMS) and its association with risk of developing lung metastasis and with primary tumor size. Experiment Overall Design: 58 tumor samples
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-5327 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human breast cancers to define clinically distinct molecular subtypes in estrogen receptor positive breast carcinomas using genomic grade
Purpose: A number of microarray studies have reported distinct molecular profiles of breast cancers (BC): basal-like, ErbB2-like and two to three luminal-like subtypes. These were associated with different clinical outcomes. However, although the basal and the ErbB2 subtypes are repeatedly recognize...
ORGANISM(S): Homo sapiens 
2008-06-20 | E-GEOD-6532 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human primary breast tumors to validate a 76-gene prognostic signature reveals strong time dependence of the 76-gene prognostic signature
Background: Recently a 76-gene prognostic signature able to predict distant metastases in lymph node-negative (N-) breast cancer patients was reported. The aims of this study conducted by TRANSBIG were to independently validate these results and to compare the outcome with clinical risk assessment. ...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-7390 | biostudies-arrayexpress
GenomicsEGAD00000000053
Sequencing data from Breast Cancer samples
EGAD00000000053 | EGA
GenomicsComplex Landscapes of Somatic Rearrangements in Human Breast Cancer Genomes
We have used massively parallel paired end sequencing strategies to reconstruct the genomic landscape of 24 breast cancer genomes, through the identification and characterization of 2166 somatically acquired genomic rearrangements. These studies have revealed considerable complexity in the patterns ...
EGAS00000000062 | EGA
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